Potential impacts of optimised care pathways on carbon impact of anaesthesia consultation - a monocenter prospective study.

Background: Global warming presents major public health challenges, with healthcare transportation significantly contributing to carbon dioxide equivalent emissions (eCO). While the greenhouse effects of anaesthetic gases are well-documented, the eCO of pre-anaesthesia consultations remains underexplored. This study aims to evaluate and propose strategies to reduce the carbon impact of these consultations at a Tertiary University Hospital.

New Insights into Bioactive Peptides: Design, Synthesis, Structure-Activity Relationship.

In recent decades, peptides have attracted significant attention not only from Academia but also from big Pharma as novel potential therapeutic compounds [...

Heterozygous variants disrupting the interaction of ERF with activated ERK1/2 cause microcephaly, developmental delay, and skeletal anomalies.

Heterozygous deleterious null alleles and specific missense variants in the DNA-binding domain of the ETS2 repressor factor (ERF) cause craniosynostosis, while the recurrent p.(Tyr89Cys) missense variant is associated with Chitayat syndrome. Exome and whole transcriptome sequencing revealed the ERF de novo in-frame indel c.

Inclusion of Cationic Amphiphilic Peptides in Fmoc-FF Generates Multicomponent Functional Hydrogels.

Peptide building blocks have been recently proposed for the fabrication of supramolecular nanostructures able to encapsulate and in vivo deliver drugs of a different nature. The primary sequence design is essential for nanostructure property modulation, directing and affecting affinity for specific drugs. For instance, the presence of positively charged residues of lysine (K) or arginine (R) could allow improving electrostatic interactions and, in turn, the encapsulation of negatively charged active pharmaceutical ingredients, including nucleic acids.