Publications by authors named "M Leo"
Purpose: We developed an electronic patient-facing family history collection tool including B-RST 3.0, PREMM risk assessments and "limited family knowledge/structure" information designed for primary care settings. We evaluated the tool's performance compared with genetic-counselor-collected information for clinical risk stratification in a population with barriers to access.
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- * The ST2/IL-33 pathway promotes immune tolerance by expanding regulatory T cells but also triggers proinflammatory cytokine production for immune defense and tissue repair.
- * Researchers developed improved ST2 inhibitors that effectively reduced ST2 upregulation and IL-1β release in human mast cells, suggesting potential for treating diseases mediated by mast cells.
Introduction: Parents of children with additional needs experience compromised physical and mental health and higher stress, and their ability to engage in meaningful occupations is impacted by their additional caregiving tasks. Online interventions targeting mental health, stress, and well-being for parents of children with additional needs have potential to increase supports alongside occupational therapy direct services. The aims of this review are to systematically identify and synthesise evidence of effectiveness of online interventions aimed at improving mental health, stress, and well-being of parents of children with additional needs.
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- Canine mast cell tumors (MCTs) have a mutated form of the KIT tyrosine kinase receptor, which is linked to abnormal growth of mast cells.
- The study aimed to evaluate how different KIT immunohistochemical expression patterns affect the survival of dogs treated with tyrosine kinase inhibitors after surgery.
- Results suggest that KIT's abnormal distribution might indicate reduced effectiveness of these inhibitors, offering valuable insight into treatment outcomes for canine MCTs.
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- Biological soil covers (BSCs) are essential for ecosystem health, improving soil stability, nutrient cycling, and hydrology, while supporting plant development.
- The eBryoSoil app enabled citizen scientists to map BSC communities in the Iberian Peninsula between November 2019 and January 2021, gathering key data despite challenges from the COVID-19 pandemic.
- The findings underline the need for conservation efforts focused on diverse habitats to protect lichen and bryophyte communities, and highlight the potential of citizen science in studying vulnerable ecosystems and organisms.