The cardinal classes are a useful simplification of cortical interneuron diversity, but such broad subgroupings gloss over the molecular, morphological, and circuit specificity of interneuron subtypes, most notably among the somatostatin interneuron class. Although there is evidence that this diversity is functionally relevant, the circuit implications of this diversity are unknown. To address this knowledge gap, we designed a series of genetic strategies to target the breadth of somatostatin interneuron subtypes and found that each subtype possesses a unique laminar organization and stereotyped axonal projection pattern.
View Article and Find Full Text PDFUnlabelled: Oral sedation for pre-cooperative and anxious pediatric patients is an important tool for the pediatric dentist. Few studies have examined the sedation regimen of meperidine and hydroxyzine.
Objectives: The primary goal of this study was to evaluate the overall safety and effectiveness of the meperidine/hydroxyzine drug combination.
Elevated dissolved organic carbon (DOC) has been detected in groundwater beneath irrigated sugarcane on the Burdekin coastal plain of tropical northeast Australia. The maximum value of 82 mg/L is to our knowledge the highest DOC reported for groundwater beneath irrigated cropping systems. More than half of the groundwater sampled in January 2004 (n = 46) exhibited DOC concentrations greater than 30 mg/L.
View Article and Find Full Text PDFTriclosan is an active agent that is commonly found in biocide formulations which are used by the food industry to control microbial contamination. The aim of this study was to use microarray analysis to compare gene expression between a triclosan-susceptible Escherichia coli O157:H19 isolate (minimum inhibitory concentration [MIC] 6.25 μg/ml) and its in vitro generated triclosan-tolerant mutant (MIC >8,000 μg/ml).
View Article and Find Full Text PDF