Publications by authors named "M Leinonen"
Importance: In pregnancy, the benefits of lithium treatment for relapse prevention in psychiatric conditions must be weighed against potential teratogenic effects. Currently, there is a paucity of information on how and when lithium is used by pregnant women.
Objective: To examine lithium use in the perinatal period.
Background: Maternal hormonal contraception use has been associated with childhood leukemia risk. However, studies are few and often based on self-reported information.
Methods: Using registry data from Denmark, Norway, and Sweden, we identified 3,183,316 children (born 1996-2018) and followed them from birth until leukemia diagnosis, censoring (death, emigration, other cancer, 20th birthday) or study closure (December 31st, 2017, 2018 or 2020).
Article Synopsis
- The study aimed to investigate if high-dose folic acid (>1 mg daily) use in women who have given birth and those with epilepsy is linked to a higher risk of cancer, especially in children born to mothers with epilepsy.
- Researchers analyzed data from medical birth registers in Denmark, Norway, and Sweden, tracking cancer diagnoses among women over time while taking into account other factors like antiseizure medication use.
- Results showed that women exposed to high-dose folic acid had a 20% increased overall risk of cancer, which slightly decreased when considering a 6-month delay, with a notable increase in non-Hodgkin lymphoma cases among those exposed.
Importance: Maternal epilepsy is associated with adverse pregnancy and neonatal outcomes. A better understanding of this condition and the associated risk of mortality and morbidity at the time of delivery could help reduce adverse outcomes.
Objective: To determine the risk of severe maternal and perinatal morbidity and mortality among women with epilepsy.
Purpose: To present the main findings of a post-authorization safety study assessing pregnancy and infant outcomes after prenatal golimumab exposure in a real-world setting.
Methods: This observational population-based cohort study included data from pregnancies ending in 2006-2018 (Finland) or 2019 (Denmark, Sweden). Infants born to women with rheumatic diseases or ulcerative colitis diagnoses were identified.