Bicontinuity analysis of multibeam interference three-dimensional periodic structures: volume fractions and interface areas.

Bicontinuous structures are an important subset of three-dimensional periodic structures. In multibeam interference structures, the conditions for bicontinuity depend on the beam parameters and the exposure dose. As described in the present work, these conditions can be applied to establish the range of bicontinuity for any multibeam-interference-produced structure.

A suppressor locus for MODY3-diabetes.

Maturity Onset Diabetes of the Young type 3 (MODY3), linked to mutations in the transcription factor HNF1A, is the most prevalent form of monogenic diabetes mellitus. HNF1alpha-deficiency leads to defective insulin secretion via a molecular mechanism that is still not completely understood. Moreover, in MODY3 patients the severity of insulin secretion can be extremely variable even in the same kindred, indicating that modifier genes may control the onset of the disease.

Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes.

A deficiency in pejvakin, a protein of unknown function, causes a strikingly heterogeneous form of human deafness. Pejvakin-deficient (Pjvk(-/-)) mice also exhibit variable auditory phenotypes. Correlation between their hearing thresholds and the number of pups per cage suggest a possible harmful effect of pup vocalizations.