Publications by authors named "M Lecuona"
The Impact of MRSA Colonization on Healthcare-Associated Infections in Long-Term Care Facility Residents: A Whole-Genome Sequencing-Based Study.
Microorganisms
November 2023
Methicillin-resistant (MRSA) colonization has been considered a risk factor for the development of infection, however, there are no studies that have compared the colonizing and infecting strains using whole-genome sequencing (WGS). The aim of this study is to determine the prevalence of and risk factors for MRSA colonization among long-term care facilities (LTCF) residents of Tenerife (Spain), and to analyze the epidemiological relationship between the colonizing and infecting strains using WGS. A point-prevalence study was carried out at 14 LTCFs in Tenerife from October 2020 to May 2021.
View Article and Find Full Text PDFEffectiveness of fosfomycin trometamol as oral step-down therapy for bacteraemic urinary tract infections due to MDR Escherichia coli: a post hoc analysis of the FOREST randomized trial.
J Antimicrob Chemother
July 2023
Article Synopsis
- Fosfomycin trometamol is being explored as a potential step-down therapy for patients with bacteraemic urinary tract infections caused by multidrug-resistant E. coli (MDR-Ec), though data is limited.
- In the FOREST trial, patients who transitioned from IV treatments to either oral fosfomycin or other oral medications showed similar clinical and microbiological cure rates, with fosfomycin achieving 78.7% success compared to 80.9% for other drugs.
- However, fosfomycin had a significantly higher relapse rate (15% vs. 4.3%), indicating that while it is a viable option, its effectiveness needs further evaluation due to this concern.
(1) Isolated systems, such as oceanic islands, are increasingly experiencing important problems related to microplastic debris on their beaches. The formation of microbial biofilm on the surface of microplastics present in marine environments provides potential facilities for microorganisms to survive under the biofilm. Moreover, microplastics act as a vehicle for the dispersion of pathogenic organisms, constituting a new route of exposure for humans.
View Article and Find Full Text PDF[Clostridioides difficile toxin B gen amplification cycle threshold as a predictor of severity].
Rev Chilena Infectol
February 2022
Background: Clostridioides dfficile infection (CDI) is the main cause of nosocomial diarrhea, generally associated with the use of antibiotics. This infection can cause uncomplicated diarrhea to pseudomembranous colitis or toxic megacolon. Recent studies have attempted to relate the threshold cycle (Ct) value of RT-PCR with mortality, as a fast, simple, objective and efficient method.
View Article and Find Full Text PDFObjective: The aim of this study was to determine and evaluate the postvaccination variation in immunoglobulin G (IgG) receptor-binding domain (RBD) produced in non-SARS-CoV-2-infected patients with nephropathy and renal replacement therapy.
Methods: This is a follow-up study of the humoral response to the BNT162b2 messenger ribonucleic acid COVID-19 vaccine in patients with nephropathy, comparing it with itself at different times and with the healthy population.
Results: In patients with nephropathy, a very striking decrease in IgG RBD was observed compared with the healthy population (P<0.