Publications by authors named "M Le Jean"

Background: Uncontrolled hypertension is the leading modifiable risk factor for cardiovascular disease mortality and remains high in low-middle income countries like Haiti. Barriers and facilitators to achieving hypertension control in urban Haiti remain poorly understood. Elucidating these factors could lead to development of successful interventions.

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This article covers the in-vessel design of the SPARC interferometry diagnostic system, highlighting unique aspects of the systems design and port plug integration in preparation for "day-1" plasma operations as a critical diagnostic for density feedback control. An early decision for the diagnostic was to deploy two lasers in the infrared wavelength spectrum, allowing the system to have a higher optical throughput. The optimization of the in-vessel geometry for the diagnostic follows a similar approach, focusing on de-risking possible damage to the plasma facing optical components by moving them further from the plasma with an orientation that provides a greater possibility for protective features to be added.

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This study used statistical tools to optimise WC/Co/Ni welds and model construction to improve the mechanical properties of coatings by laser cladding. The effect of the parameters on the wear performance of the weld was determined by analysis of variance. In addition, a polynomial model was constructed using the response surface method based on the experimental data of the orthogonal array designed by Taguchi.

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Biallelic mutations in BRAT1 result in lethal neonatal rigidity and multifocal seizure syndrome and a milder neurodevelopmental disorder of cerebellar atrophy with or without seizures (NEDCAS, MIM 618056). Combining linkage analysis and whole-genome sequencing (WGS), we identified a novel deep intronic BRAT1 variant, NC_000007.14 (NM_152743.

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With plasma currents up to 8.7 MA, the SPARC tokamak runs the risk of forming multi-MA beams of relativistic "runaway" electrons (REs), which could damage plasma facing components if unmitigated. The infrared (IR) and visible imaging and visible spectroscopy systems in SPARC are designed with measurements of synchrotron emission from REs in mind.

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