Combination of Hotspot Mutations With Methylation and Fragmentomic Profiles to Enhance Multi-Cancer Early Detection.

Background: Multi-cancer early detection (MCED) through a single blood test significantly advances cancer diagnosis. However, most MCED tests rely on a single type of biomarkers, leading to limited sensitivity, particularly for early-stage cancers. We previously developed SPOT-MAS, a multimodal ctDNA-based assay analyzing methylation and fragmentomic profiles to detect five common cancers.

Ecological and anthropogenic effects on the genomic diversity of lemurs in Madagascar.

Ecological variation and anthropogenic landscape modification have had key roles in the diversification and extinction of mammals in Madagascar. Lemurs represent a radiation with more than 100 species, constituting roughly one-fifth of the primate order. Almost all species of lemurs are threatened with extinction, but little is known about their genetic diversity and demographic history.

Identifying Predictors of Successful Conversion from OREF Grants to Extramural Federal Funding Among Orthopaedic Surgeons.

Background: Musculoskeletal diseases are a major contributor to global human disability, but research in this area of medicine contends with chronic underfunding in the United States, receiving <2% of the National Institutes of Health (NIH) budget. The Orthopaedic Research and Education Foundation (OREF) serves as a vital nongovernmental organization, providing essential support for orthopaedic research. This study investigated the translation of various OREF grants into successful extramural federal funding discerning the clinician demographics and OREF award characteristics associated with increased chances of securing federal grants.

Detection of decline in estimated glomerular filtration rate in patients with type 2 diabetes by cystatin C-based equations.

Background: Aging population is a significant issue in Viet Nam and across the globe. Elderly individuals are at higher risk of chronic kidney disease (CKD), especially those with diabetes. Several studies found that the estimated glomerular filtration rate (eGFR) determined using creatinine-based equations was not as accurate as that determined using cystatin C-based equations.

Modeling-Facilitated Field Survey Discovers of a New Population of the Annamite Striped Rabbit in Kon Tum Province, Vietnam.

The Annamite striped rabbit () is an Endangered lagomorph endemic to the Annamite Mountain Range in Vietnam and Laos, with much unknown about its distribution range. In this study, we used previously known records of the Annamite striped rabbit to construct distribution models using Maxent, a modeling approach that has been proven to be robust in identifying potential areas of undiscovered populations of targeted species. Using the optimal model results as a guideline to select the field site, we conducted a systematic camera trap survey in Dak Long Protection Forest, Kon Tum Province, Vietnam.