Publications by authors named "M Lavignon"
Previous studies indicate that mice infected with mixtures of mouse retroviruses (murine leukemia viruses [MuLVs]) exhibit dramatically altered pathology compared to mice infected with individual viruses of the mixture. Coinoculation of the ecotropic virus Friend MuLV (F-MuLV) with Fr98, a polytropic MuLV, induced a rapidly fatal neurological disease that was not observed in infections with either virus alone. The polytropic virus load in coinoculated mice was markedly enhanced, while the ecotropic F-MuLV load was unchanged.
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- The study compared HIV-1 residual viremia levels in patients on two different treatment regimens: nevirapine (NVP) and efavirenz (EFV), focusing on those with suppressed viral loads.
- Among 165 patients, those on NVP showed a significantly higher percentage (81.3%) of having viral loads below 1 copy/ml compared to those on EFV (55.6%).
- The findings suggest that NVP might provide better control of viral replication, warranting further research into its clinical implications, such as its effects on inflammation and immune activation.
Article Synopsis
- Switching to a non-nucleoside reverse transcriptase inhibitor (NNRTI) regimen for HIV-infected patients with controlled viral loads was found to be safe and effective, leading to improvements in health-related quality of life (HRQL).
- A noticeable decrease in anxiety was observed by 6 months, with significant reductions in various symptoms and improvements in the physical, independence, and spirituality aspects of HRQL also recorded.
- The study highlighted that these positive changes in mental health and HRQL began at one month after the switch and were maintained over a year, despite no change in depression levels.
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- A study involving 143 patients previously treated with protease inhibitors analyzed mutations linked to the effectiveness of a tipranavir-ritonavir (TPV/r) regimen, measuring VR as a significant reduction in HIV RNA levels after 3 months.
- Specific mutations at six locations were identified as associated with a lower virological response, while one mutation was linked to a higher response, with a genotypic score indicating strong associations with VR outcomes.
- Non-clade B virus infections showed a significantly lower response to the TPV/r treatment compared to clade B infections, likely due to a greater prevalence of certain mutations in non-B subtype patients.
Article Synopsis
- Mixed retrovirus infections are common in mice and other species, including humans, but their interactions and effects on disease are not well understood.
- In experiments with mice infected by ecotropic Friend murine leukemia virus (F-MuLV) and polytropic viruses, it was found that mixed infections can dramatically alter disease outcomes; one combination prolonged survival while another caused severe neurological issues.
- The study highlights how the presence of multiple retroviruses can lead to significant viral amplification and changes in disease processes, indicating that co-infections can dramatically impact viral behavior and severity of illness.