Publications by authors named "M Laura Colombo"
Background: The 3D models' use for surgical planning has recently gained an ever-wider popularity, in particular in the urological field. Different ways of fruition of this technology have been evaluated over the years. Today, new technological developments allow us to enjoy 3D models in the metaverse.
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- The measurement of mechanical properties between cancer and benign cells can aid in disease detection and classification, but current methods struggle with high-throughput evaluations in clinical settings.!* -
- A new ultrahigh-throughput viscoelastic microfluidic platform allows for single-cell mechanical property measurements at speeds of up to 100,000 cells per second, addressing the need for faster diagnostic techniques.!* -
- This platform has demonstrated utility in analyzing tumor biopsies, studying drug effects on cell structures, and identifying cancerous lymphocytes in blood samples, paving the way for improved clinical diagnostics and personalized medicine.!*
Importance: Safe and effective long-term treatments for moderate to severe plaque psoriasis are needed.
Objective: To evaluate the long-term safety and efficacy of deucravacitinib through 3 years (week 148) in the randomized POETYK PSO-1, PSO-2, and nonrandomized long-term extension (LTE) trials.
Design, Setting, And Participants: PSO-1/PSO-2 were global, 52-week, randomized, double-blinded phase 3 trials in patients with moderate to severe plaque psoriasis.
Many proteins used in industrial and pharmaceutical applications are typically synthesized within the secretory pathway. While yeast and mammalian cells have been engineered to enhance the production of endomembrane-targeted proteins, similar strategies in plant cells remain underexplored. This study investigates the potential of arabidopsis leafy cotyledon 2 (AtLEC2), a key regulator of seed development, to enhance the production of proteins targeted to the endoplasmic reticulum (ER) in Nicotiana benthamiana leaves.
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