Publications by authors named "M Laschinger"
Article Synopsis
- Natural killer (NK) cells are vital for fighting metastasis, but disseminated tumor cells (DTCs) in the lungs release prostaglandin E2 (PGE), which leads to NK cell dysfunction.
- This dysfunction is triggered by PGE binding to specific receptors (EP2 and EP4), altering NK cell gene expression and reducing the production of important anti-metastatic signals.
- Targeting the PGE-EP2/EP4 pathway may provide a new therapeutic strategy to enhance NK cell activity against metastatic tumors in distant organs.
The liver is innervated by primary sensory nerve fibres releasing the neuropeptide calcitonin gene-related peptide (CGRP). Elevated plasma levels of CGRP have been found in patients with liver fibrosis or cirrhosis. We hypothesised that signalling of CGRP and its receptors might regulate liver fibrosis and propose a novel potential target for the treatment.
View Article and Find Full Text PDFSolid cancers like pancreatic ductal adenocarcinoma (PDAC), a type of pancreatic cancer, frequently exploit nerves for rapid dissemination. This neural invasion (NI) is an independent prognostic factor in PDAC, but insufficiently modeled in genetically engineered mouse models (GEMM) of PDAC. Here, we systematically screened for human-like NI in Europe's largest repository of GEMM of PDAC, comprising 295 different genotypes.
View Article and Find Full Text PDFBackground & Aims: Hepatocyte growth and proliferation depends on membrane phospholipid biosynthesis. Short-chain fatty acids (SCFAs) generated by bacterial fermentation, delivered through the gut-liver axis, significantly contribute to lipid biosynthesis. We therefore hypothesized that dysbiotic insults like antibiotic treatment not only affect gut microbiota, but also impair hepatic lipid synthesis and liver regeneration.
View Article and Find Full Text PDFBackground & Aims: Increased sensitivity towards tumor necrosis factor (TNF)-induced cell death in virus-infected hepatocytes has revealed a so far unrecognized hepatocyte-intrinsic antiviral immune surveillance mechanism, for which no or model is available. We aimed to establish precision-cut liver slices (PCLS) as a model system to study hepatocyte-intrinsic regulation of apoptosis.
Methods: Preparation of PCLS from mouse and human liver tissue was optimized for minimal procedure-associated apoptosis.