Publications by authors named "M Larroque"
Article Synopsis
- Dedifferentiated and Well-differentiated liposarcoma tumors show an increase in the MDM2 oncogene, which drives tumor growth through unique metabolic functions.
- The study finds that liposarcoma cells rely on serine produced by distant muscle tissues for survival, although the source of serine is not fully understood.
- Treatment with an FDA-approved anti-interleukine-6 monoclonal antibody can hinder serine synthesis and lead to decreased tumor growth and increased cancer cell death, suggesting a potential therapy for liposarcoma patients.*
Eukaryotic genomes are duplicated from thousands of replication origins that fire sequentially forming a defined spatiotemporal pattern of replication clusters. The temporal order of DNA replication is determined by chromatin architecture and, more specifically, by chromatin contacts that are stabilized by RIF1. Here, we show that RIF1 localizes near newly synthesized DNA.
View Article and Find Full Text PDFObjective: To identify the consequences of technology overuse in childhood.
Data Source: A systematic review was carried out in the electronic databases PubMed (National Library of Medicine of the National Institutes of Health) and BVS (Virtual Health Library), considering articles published from 2015 to 2020, in English, Portuguese and Spanish using the terms "Internet", "Child" and "Growth and Development".
Data Synthesis: 554 articles were found and 8 were included in the analysis.
Article Synopsis
- - Personalized cancer treatments have become essential in oncology, leading to better outcomes but also increasing the focus on long-term side effects for survivors, with 5-10% facing severe late toxicity from radiotherapy.
- - The identification of patients at risk for severe side effects before treatment can allow adjustments in their care to enhance their quality of life, for which various tests and biomarkers have been created over the years.
- - Among these tests, the Radiation-Induced Lymphocyte Apoptosis (RILA) assay has been the only one prospectively validated on a large scale and shows promise in predicting late radiation-induced toxicity across multiple cancer types, aiding decision-making in precision radiation oncology.
Mass Spectrometry Imaging is an effective technology that allows to determine the in-situ distribution of endogen and/or exogen small molecules. It is a rapidly emerging approach for visualizing drugs and their metabolites within biological tissues. Matrix-Assisted Laser Desorption Ionization (MALDI) Mass Spectrometry Imaging (MSI) coupled to high resolving power analyzer (e.
View Article and Find Full Text PDF