Publications by authors named "M Laposata"

Considering laboratory results are used to make medical decisions, a fundamental understanding of laboratory medicine is paramount to enhance patient care, optimize health care cost containment, and prevent legal repercussions. With increasing laboratory testing complexity, this education is needed now more than ever. This article is a call to action to have medical schools adequately incorporate practical laboratory medicine content into their undergraduate medical education (UME) curricula.

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Objectives: Diagnostic management teams (DMT) are groups of experts with specialized knowledge to guide test selection and interpretation of results. They have been active in institutions over the past 20 years. To date, there are limited data on whether the presence of experts to advise healthcare providers on appropriate laboratory test selection and interpretation of complex test results positively impacts patient care.

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This review article summarizes the conclusions of the National Academy of Medicine committee on diagnostic error. The committee deliberated during five in-person meetings and during numerous conference calls between April 2014 and April 2015. At three of the meetings, the committee invited multiple speakers to inform its deliberations.

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Article Synopsis
  • Coagulopathy, which involves problems with blood clotting, is linked to inflammation and infections like COVID-19 caused by SARS-CoV-2, indicating a complex relationship between these conditions.
  • A protein called von Willebrand factor (vWF) is released during inflammation, and its secretion is regulated by EPAC1, an intracellular receptor that generally helps suppress inflammation.
  • Studies using EPAC1-deficient mice showed that without EPAC1, there was increased vWF release during inflammation, suggesting that targeting EPAC1 could be a new approach to managing blood clotting issues associated with inflammatory conditions.
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