[Towards more informed consent: Making information understandable].

In clinical research and care, information notices are too often reduced to complicated and hard-to-understand mandatory documents. However, every person has the right to transparent and truthful information. These considerations prompted the creation of a multidisciplinary working group in the fall of 2020, headed by the College des relecteurs de l'Inserm.

[Patients' contribution to the review of research protocols].

Involvement of patients in the ethical management of research protocols began by patients' associations involved in the fight against AIDS in France in the 1990s. It was the first step towards recognizing the major role of patients in research that concerns them. This article aims describing this emancipation and its consequences on the evolution of research by drawing on two experiences: 1) The one of the « Comité de patients pour la recherche clinique » founded in 1998 by the « Ligue nationale contre le cancer » and by the « Fédération nationale des centres de lutte contre le cancer »; 2) The one of the « Collège des relecteurs de l'Inserm » set up in 2007.

Immunogenicity and safety in adults of a new chromatographically purified Vero-cell rabies vaccine (CPRV): a randomized, double-blind trial with purified Vero-cell rabies vaccine (PVRV).

Recent improvements in chromatographic purification procedures have made it possible to develop a new chromatographically purified rabies vaccine (CPRV) by further purifying the current rabies vaccine prepared from Vero-cell culture (Verorab; Pasteur Mérieux Connaught). The immunogenicity and safety of primary immunization, followed by a booster at one year, with CPRV was compared to that of the purified Vero cell vaccine (PVRV) in a randomized, double-blind study carried out at four veterinary schools in France. A total of 330 healthy, male and female, first-year veterinary students, aged at least 18 years and who required pre-exposure rabies prophylaxis, were enrolled in this study.

[Functional results following complicated injuries of the extremities--how can they be improved?].

This study evaluates the critical points in the management of 48 patients with injured arteries of the lower limb between 1980 and 1986. 77% of the traumas were resultant from blunt vehicular traffic mishaps. 13 patients were treated within 6 h, 8 patients later than 6 h, 21 patients later than 24 h post injury.