Publications by authors named "M Lamoree"

Article Synopsis
  • Effect-Directed Analysis (EDA) was utilized to pinpoint bioactive compounds in surface and well water from the Upper Rhine, assessing their persistence and toxicity based on PMT and vPvM criteria.
  • A multi-layered solid-phase extraction enriched polar substances, leading to the fractionation of samples into 108 parts that underwent testing with specific bioassays to identify bioactive compounds.
  • The study successfully identified ten bioactive substances, including several classified as PMT/vPvM, highlighting the role of EDA in environmental risk assessment and regulatory prioritization.
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Article Synopsis
  • - This study investigates the effects of different sizes and concentrations of polystyrene micro- and nanoplastics (PS-MNPs) on hormone receptor activity and steroid production in lab cell cultures, despite the lack of prior research on their endocrine-disrupting properties.
  • - Experimentation revealed that while PS-MNPs were taken up by various cell types, they did not significantly impact estrogen or androgen receptor activity; however, they did alter hormone levels, particularly decreasing estriol and increasing oxidative stress markers in certain cells.
  • - The findings suggest that PS-MNPs have limited endocrine-disrupting effects overall, but the notable changes in estriol levels provoke further investigation into the potential risks of MNPs during pregnancy. *
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The rapid increase in the production and global use of chemicals and their mixtures has raised concerns about their potential impact on human and environmental health. With advances in analytical techniques, in particular, high-resolution mass spectrometry (HRMS), thousands of compounds and transformation products with potential adverse effects can now be detected in environmental samples. However, identifying and prioritizing the toxicity drivers among these compounds remain a significant challenge.

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