Publications by authors named "M Lahodna"
Article Synopsis
- Hereditary angioedema (HAE) is a serious condition linked to mutations in the C1 inhibitor gene, leading to variable symptoms even among affected family members.
- Researchers investigated the potential influence of genetic variations in several genes (BDKR1, BDKR2, ACE, MBL2) on HAE in 36 unrelated patients and 69 patients overall, but found no significant impact on disease severity or attack characteristics.
- The findings suggest that additional genetic and environmental factors may contribute to the clinical differences observed in HAE among Caucasian patients.
Polymorphic variants of B2 receptors for bradykinin (B2BKR) have been postulated to influence a clinical manifestation of hereditary angioedema. In this study, exon 1 nonanucleotide deletion polymorphism in the B2BKR gene was examined in 37 patients with hereditary angioedema. The patients were grouped according to disease severity or the age of the first clinical manifestation of disease.
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