Publications by authors named "M Lahaye"
Background/aims: X-linked retinitis pigmentosa (XLRP) is considered one of the most severe forms of retinitis pigmentosa (RP), accounting for 5-15% of all RP cases and primarily affecting males. However, the real-world humanistic impacts of this disease on patients are poorly investigated, especially with respect to burdens faced by patients with varying disease severities.
Methods: EXPLORE XLRP-2 was an exploratory, multicentre, non-interventional study.
Article Synopsis
- Diagnostic imaging is crucial for treating ovarian and colorectal cancer by helping choose the best treatment options and assessing risks associated with them.
- A joint guideline was created by multiple medical societies to address challenges in detecting and reporting peritoneal metastases, using literature reviews and consensus methods.
- The consensus outlines key recommendations for best practices in imaging techniques, ensuring effective communication of results, and supporting clinical decisions regarding operability and treatment monitoring in affected patients.
Purpose: This study aimed to evaluate the added benefit of body MRI (covering the chest, abdomen, and pelvis) to detect the primary tumour in patients with adenocarcinoma of unknown primary (ACUP) and a suspected abdominal malignancy in whom previous diagnostic work-up with CT and/or FDG-PET/CT did not yield a primary tumour diagnosis.
Methods: Thirty ACUP patients with a suspected primary tumour in the abdomen/pelvis (based on pathology and/or pattern of disease) underwent MRI (T2-weighted, DWI, pre- and post-contrast T1-weighted) after completion of their initial diagnostic work-up with CT and/or PET/CT. Effects of MRI to establish a primary tumour diagnosis (and to detect additional metastatic sites) were documented.
Introduction: DW-MRI is a non-invasive way to determine the peritoneal cancer index (PCI) in colorectal cancer (CRC) patients with peritoneal metastases (PM). However, like surgeons during surgery, radiologists struggle to differentiate between PM and fibrosis. This study aimed to investigate the agreement between the PCI as determined by MRI (mriPCI), during surgery (sPCI) and histopathology examination (pPCI) in CRC patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC).
View Article and Find Full Text PDFIdentifying the primary tumour in patients with cancer of unknown primary (CUP) using [F]FDG PET/CT: a systematic review and individual patient data meta-analysis.
Eur J Nucl Med Mol Imaging
December 2024
Article Synopsis
- - This systematic review and meta-analysis evaluated how effective [F]FDG PET/CT scans are in identifying the primary tumors in patients with cancer of unknown primary (CUP) based on the location of their predominant metastatic sites.
- - The study analyzed 1865 patients from 32 studies, finding that the detection rates for primary tumors varied by metastatic site, with brain metastases showing the highest detection rate of 74%, while soft tissue metastases had the lowest at 35%.
- - The results indicate that the performance of [F]FDG PET/CT is influenced by where the metastases are located, suggesting a need for customized diagnostic strategies and further exploration of alternative imaging techniques.