Publications by authors named "M Lada"
Article Synopsis
- Candida auris cases in Greece rose significantly after 2019, leading to active surveillance from November 2019 to September 2021 in 11 hospitals, focusing on confirmed infections and outbreaks.
- A study identified 20 invasive infections and 25 colonized cases, with high mortality (53%) and common risk factors such as the use of indwelling devices and previous antibiotic treatments.
- The fungus showed resistance to fluconazole in all isolates and was mostly linked to a specific South Asian strain, highlighting the need for improved infection control measures in healthcare settings.
Oral minocycline plus rifampicin versus oral linezolid for complicated skin and skin structure infections caused by methicillin-resistant : The AIDA open label, randomized, controlled Phase 4 trial.
EClinicalMedicine
February 2023
Background: The need for oral, cost-effective treatment for complicated skin and skin structure infections (cSSSIs) due to methicillin-resistant (MRSA) was addressed by the non-inferiority comparisons of oral minocycline plus rifampicin with linezolid.
Methods: In the AIDA multicenter, open label, randomized, controlled clinical trial, hospitalized adults with cSSSI and documented MRSA were randomly assigned at a 2:1 ratio to either oral 600 mg rifampicin qd plus 100 mg minocycline bid or oral 600 mg linezolid bid for 10 days. The primary endpoint was the clinical cure rate in the clinically evaluable (CE) population at the test-of-cure visit (14 days).
Estimation of the determinants for HIV late presentation using the traditional definition and molecular clock-inferred dates: Evidence that older age, heterosexual risk group and more recent diagnosis are prognostic factors.
HIV Med
December 2022
Article Synopsis
- HIV late presentation (LP) is on the rise in Europe, particularly in Greece, prompting an investigation into the characteristics and factors influencing LP, defined by the time between HIV infection and diagnosis.
- Analysis of data from 6166 people living with HIV in Greece from 1999-2015 revealed that older age, heterosexual transmission, and more recent diagnoses correlate with a higher risk of LP, while individuals who inject drugs tend to get diagnosed more quickly than other groups.
- The findings highlight the need for focused healthcare interventions for older adults and heterosexuals, who are increasingly at risk for LP as they represent a growing segment of new diagnoses in Greece.
Background: Clarithromycin may act as immune-regulating treatment in sepsis and acute respiratory dysfunction syndrome. However, clinical evidence remains inconclusive. We aimed to evaluate whether clarithromycin improves 28-day mortality among patients with sepsis, respiratory and multiple organ dysfunction syndrome.
View Article and Find Full Text PDFDiabetes is a common comorbidity in the U.S. and is associated with adverse outcomes in a variety of disease processes.
View Article and Find Full Text PDF