Publications by authors named "M Lacle"
Background: Similar to T1 colon cancer (CC), risk stratification may guide T2 CC treatment and reduce unnecessary major surgery. In this study, prediction models were developed that could identify T2 CC patients with a lower risk of lymph node metastasis (LNM) for whom (intensive) follow-up after local treatment could be considered.
Methods: A nationwide cohort study was performed involving pT2 CC patients who underwent surgery between 2012 and 2020, using data from the Dutch ColoRectal Audit, which were linked to the Nationwide Pathology Databank.
Paucity of gastrointestinal plasma cells in common variable immunodeficiency.
Curr Opin Allergy Clin Immunol
December 2024
Purpose Of Review: Common variable immunodeficiency enteropathy (CVID-E) is a noninfectious complication of CVID caused by chronic inflammation of the gastrointestinal (GI) tract. Based on literature, a paucity or lack of plasma cells, although not obligatory for diagnosis, is a pathognomonic feature of CVID and more frequent in CVID-E. However, there is no consensus on standardized histopathological analysis of this feature in biopsies.
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- Detection of lymphovascular invasion (LVI) in T1 colorectal cancer (CRC) varies across Dutch laboratories and significantly influences treatment decisions, particularly surgical resection rates.
- Patients diagnosed in laboratories with high LVI detection rates had higher surgical resection rates and a greater proportion of lymph node metastasis-negative surgeries compared to those from lower detection rate labs.
- However, despite these differences in surgical approach, high LVI detection did not lead to significantly better cancer recurrence outcomes, indicating potential risks without improved benefits for patients.
Background: International consensus on classifications of appendiceal mucinous neoplasms (AMNs) and associated pseudomyxoma peritonei (PMP) have been carefully made but clinicopathological associations supporting decision making remain scarce.
Objective: This study aimed to assess interdependence between AMNs and PMP and provide directions for clinical management.
Methods: This two-center retrospective cohort study reviewed patients with PMP treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy between 2005 and 2021.