Publications by authors named "M Labriola"
Article Synopsis
- The study investigated the sound patterns of a newly examined dolphin population in the Mediterranean, focusing on how environmental and social factors influence their vocalizations.
- Findings showed that dolphins emitted more whistles and clicks when in larger groups or with calves present, with specific acoustic features changing based on behavior and environmental conditions.
- The research revealed that dolphins have a flexible acoustic communication system, affected by social interactions and habitat conditions, highlighting the need for more localized studies on their communication.
Article Synopsis
- The study assessed the effectiveness of poly(ADP-ribose)polymerase inhibitors (PARPi) and platinum chemotherapy in men with prostate cancer (PC) and specific genetic mutations related to DNA repair.
- It utilized data from the PROMISE consortium to compare outcomes between three groups based on their mutation profiles: one with direct BRCA complex interactions and two without.
- Results showed that patients with BRCA mutations had significantly better responses to PARPi, including higher PSA response rates and longer progression-free survival, compared to those without direct BRCA interactions.
Clinical implications of Wnt pathway genetic alterations in men with advanced prostate cancer.
Prostate Cancer Prostatic Dis
July 2024
Article Synopsis
- Aberrant Wnt signaling is linked to advanced prostate cancer, but its genetic impact on patients is still uncertain.
- A study analyzed data from the PROMISE database, finding that 12.9% of patients had Wnt alterations which were associated with significantly higher rates of liver and lung metastases compared to those without these alterations.
- Despite the increased prevalence of other genetic mutations in Wnt-altered patients, there were no significant differences in overall survival or treatment outcomes between groups.
Article Synopsis
- The study looked at how often men with advanced prostate cancer get tested with a special method called next-generation sequencing (NGS) to find helpful information about their disease.
- They analyzed data from 1,597 patients and found that only 9% had more than one NGS test, often discovering new useful information on the second test.
- The results suggest that doing these tests more than once could help doctors make better treatment choices for men with advanced prostate cancer.
Patients with cancer have the unique ability of being able to offer valuable insights into how cancer therapeutics may impact the overall patient experience and improve clinical outcomes. Patient engagement could therefore contribute to tailoring treatment strategies and research design according to patient needs. This study evaluated patient engagement in prostate cancer research by identifying patient input in the prostate cancer literature.
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