Uniportal video-assisted thoracic surgery resection of subsolid or millimetric nodules using an innovative micro-coil technique: our experience.

Background: Sometimes, the identification of ground-glass opacities (GGOs), small or deep pulmonary nodules can be difficult also in expert hands. Usually for these lesions pulmonary lobectomy is an overtreatment, so we developed a technique to identify easily these nodules. The objective of this research is to assess the effectiveness and safety of using preoperative cone beam computed tomography (CBCT) to guide the placement of micro-coils in the lung parenchyma near GGO and small lesions.

Cardiomyocyte and stromal cell cross-talk influences the pathogenesis of arrhythmogenic cardiomyopathy: a multi-level analysis uncovers DLK1-NOTCH pathway role in fibro-adipose remodelling.

Arrhythmogenic Cardiomyopathy (ACM) is a life-threatening, genetically determined disease primarily caused by mutations in desmosomal genes, such as PKP2. Currently, there is no etiological therapy for ACM due to its complex and not fully elucidated pathogenesis. Various cardiac cell types affected by the genetic mutation, such as cardiomyocytes (CM) and cardiac mesenchymal stromal cells (cMSC), individually contribute to the ACM phenotype, driving functional abnormalities and fibro-fatty substitution, respectively.

Bifunctional heterobimetallic 3d-4f [Co(II)-RE, RE = Dy, Eu, and Y] ionic complexes: modulation of the magnetic-luminescence behaviour.

This work reports the engineering and functional properties of an emerging class of heterobimetallic 3d-4f ionic complexes designed with cobalt and rare-earth (RE) metals. We present a comprehensive examination of the structural, magnetic, optical, and thermal properties of the heterobimetallic ionic complexes with the general formula [Co(hfa)][RE(hfa)tetraglyme] (RE = Dy, Eu, and Y), where the metal centres are coordinated by hexafluoroacetylacetonate (Hhfa = 1,1,1,5,5,5-hexafluoro-2,4-pentanedione), β-diketone and tetraglyme (2,5,8,11,14-pentaoxapentadecane) polyether. Structural analysis reveals an octahedral coordination geometry enveloping the cobalt(II) centre, characterized by inherent symmetry properties consistent across the derivatives, while a capped square-antiprism coordination polyhedron is observed for the RE ions.

Capacity to Consent in Healthcare: A Systematic Review and Meta-Analysis Comparing Patients with Bipolar Disorders and Schizophrenia Spectrum Disorders.

: Mental capacity is a fundamental aspect that enables patients to fully participate in various healthcare procedures. To assist healthcare professionals (HCPs) in assessing patients' capacity, especially in the mental health field, several standardized tools have been developed. These tools include the MacArthur Competence Assessment Tool for Treatment (MacCAT-T), the MacArthur Competence Assessment Tool for Clinical Research (MacCAT-CR), and the Competence Assessment Tool for Psychiatric Advance Directives (CAT-PAD).

Ebselen analogues with dual human neutrophil elastase (HNE) inhibitory and antiradical activity.

Human neutrophil elastase (HNE) plays an essential role in host defense against bacteria but is also involved in several respiratory diseases. Recent reports suggest that compounds exhibiting a combination of HNE inhibitory activity with antiradical properties may be therapeutically beneficial for the treatment of respiratory diseases involving inflammation and oxidative stress. We report here the synthesis and biological evaluation of novel ebselen analogues exhibiting HNE inhibitory and antiradical activities.