Publications by authors named "M L Zappia"
Article Synopsis
- The study investigates two phenotypes of Parkinson's Disease (PD) based on the timing of REM sleep behavior disorder (RBD) onset in relation to motor symptoms: "body first" (RBD before motor symptoms) and "brain first" (RBD after motor symptoms).
- Researchers analyzed striatal dopaminergic function in PD patients using imaging and found that the "body first" group exhibited more symmetrical motor impairment, higher cognitive decline, and distinctive imaging results compared to those with later onset RBD.
- The findings corroborate the SOC model's predictions, indicating different patterns of neurological function and cognitive impairment linked to the onset of RBD in PD.
Background: L-dopa (LD) effects on visually guided saccades (VGS) have been poorly investigated in de novo Parkinson's disease (PD) patients through a standardized acute challenge test.
Objectives: To assess the acute saccadic effects of LD as well as possible different patterns of VGS response to LD in a consistent population of de novo PD.
Methods: VGS were assessed among de novo PD at baseline and 2 h after the administration of LD/carbidopa 250/25 mg.
The challenge of thigh tendon reinjuries: an expert opinion.
J Basic Clin Physiol Pharmacol
November 2024
This review critically examines the issue of thigh tendon reinjury in athletes, drawing on recent advancements and diverse perspectives in sports medicine. The findings underscore the paramount importance of an early and accurate diagnosis, which significantly influences treatment efficacy and rehabilitation outcomes. We explore the intricacies of tendon anatomy and the mechanisms underlying injuries, highlighting how these factors interplay with athlete-specific risk profiles to affect reinjury rates.
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- * The research involved 230 patients, analyzing their EEG recordings to determine a power law exponent (β) that reflects brain connectivity and activity patterns.
- * Results showed that tauopathies had lower β values compared to α-synucleinopathies, suggesting that β could serve as a potential biomarker for distinguishing between these two types of neurodegenerative diseases.
Article Synopsis
- Numerous biomarkers have been proposed to distinguish Parkinson's disease (PD) from similar conditions, but many require expensive technology and are not practical for regular clinical use.
- Current research has primarily relied on small patient groups and manual MRI measurement techniques, leading to inconsistencies in results.
- The review emphasizes the need for larger, international studies and simpler biomarkers that can differentiate diseases, identify disease subtypes, track progression, and potentially predict PD in its early stages.