Simultaneous degradation of roxithromycin and nitrogen removal by Acinetobacter pittii TR1: Performances, pathways, and mechanisms.

Pharmaceutical and aquaculture wastewater contains not only antibiotics but also high concentrations of nitrogen, but few studies have been conducted on bacteria that target this complex pollution for degradation. A novel heterotrophic nitrifying aerobic denitrifying (HN-AD) strain Acinetobacter pittii TR1 isolated from soil. When the C/N ratio was 20, the strain could degrade 50 mg/L roxithromycin (ROX) and the nitrogen removal rate was 96.

Influence of sewage sludge compost on heavy metals in abandoned mine land reclamation: A large-scale field study for three years.

Using sewage sludge compost (SSC) for abandoned mine land reclamation supports ecological sustainability, but the environmental behavior of heavy metals in this process lacks systematic field validation. Here we analyzed the dynamic changes in heavy metal composition in topsoil, surface runoff, and subsurface infiltration after large-scale reclamation. Results show that SSC application promoted plant growth by 2-4 times, enhanced the physicochemical structure of the topsoil, and increased the levels of organic matter and inorganic nutrients.

Mesoporous silica nanoparticles as sensitizers: A novel approach to enhancing shear wave elastography in liver stiffness measurement.

Purpose: The objective of this study is to elucidate the sensitizing effect of mesoporous silica nanoparticles (MSNs) on shear wave elastography (SWE) and to investigate the potential application of MSNs as a sensitizer to enhance the sensitivity of SWE in the diagnosis of metabolic-associated steatohepatitis (MASH).

Materials And Methods: The in vitro gelatin models with varying ratios were assessed using SWE to identify the gelatin ratio that most closely approximates with human liver stiffness. Following the characterization of the dispersion properties of MSNs, in vitro models incorporating MSNs of different particle sizes were developed.

An Expanded Registry of Candidate cis-Regulatory Elements for Studying Transcriptional Regulation.

Mammalian genomes contain millions of regulatory elements that control the complex patterns of gene expression. Previously, The ENCODE consortium mapped biochemical signals across many cell types and tissues and integrated these data to develop a Registry of 0.9 million human and 300 thousand mouse candidate cis-Regulatory Elements (cCREs) annotated with potential functions .

Polymorphisms in genes related to inflammation and endothelial function are associated with ischemic stroke and other vascular events in populations at high risk of stroke.

Background: The association of genetic single-nucleotide polymorphisms (SNPs) related to endothelial function, inflammation, and their outcomes remains poorly studied.

Objectives: To evaluate the occurrence of ischemic stroke (IS) and other vascular events, and relationships between 19 SNPs in genes associated with endothelial function and inflammation with outcomes in a population at high risk of stroke.

Design: A prospective cohort study and multi-center community-based sectional survey.