Publications by authors named "M L Van Velthuysen"
Clinicopathological and epigenetic differences between primary neuroendocrine tumors and neuroendocrine metastases in the ovary.
J Pathol Clin Res
November 2024
Article Synopsis
- Current research lacks clarity in distinguishing between primary ovarian neuroendocrine tumors (PON) and neuroendocrine ovarian metastases (NOM), prompting a study of patient data spanning 1991 to 2023, which identified 71 NOM and 17 PON cases.
- Analysis revealed that PON tumors are usually unilateral, often found in teratomas, while NOM are predominantly bilateral and not associated with teratomas.
- The findings suggest a need for different treatment approaches; unilateral PON within teratomas should be treated as PON, while PON without teratoma components show similarities to midgut NET metastases, requiring thorough imaging to check for hidden midgut NET.
• This Clinical Practice Guideline provides key recommendations for managing rare endocrine tumours. • Neuroendocrine neoplasms of different origins, parathyroid carcinoma and intrathyroid thymic neoplasms are included. • The guideline covers clinical imaging and pathological diagnosis, staging and risk assessment, treatment and follow-up.
View Article and Find Full Text PDFNeoadjuvant therapy (NAT) has become routine in patients with borderline resectable pancreatic cancer. Pathologists examine pancreatic cancer resection specimens to evaluate the effect of NAT. However, an automated scoring system to objectively quantify residual pancreatic cancer (RPC) is currently lacking.
View Article and Find Full Text PDFArticle Synopsis
- The incidence and prevalence of well-differentiated small intestine neuroendocrine tumors (Si-NET) are rising, with most cases being non-functioning and often discovered incidentally during routine procedures or late-stage imaging.
- About 30% of patients experience symptoms related to the carcinoid syndrome, highlighting the disease's subtle presentation.
- Effective treatment planning requires thorough biochemical assessment and staging, ideally conducted in specialized ENETS Centres of Excellence or expert centers, as outlined in guidance focusing on management strategies for Si-NET grades 1-3.
Neuroendocrine tumors (NETs) are malignant neoplasms that can be associated with specific hormonal syndromes. We describe a novel syndrome of postmenopausal vaginal bleeding and ovarian estradiol overproduction due to ovarian NET localizations. An extensive workup was performed for 2 index patients with ovarian metastases of small bowel neuroendocrine tumors and symptoms of postmenopausal vaginal bleeding.
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