Publications by authors named "M L Tung"
We introduce a 39-year-old man with an exceedingly large adrenal schwannoma who visited our outpatient department with epigastric pain and a palpable mass in the left upper abdomen. Abdominal computed tomography revealed a giant cystic lesion measuring >25 cm. Laparotomy was performed for tumor excision and partial nephrectomy.
View Article and Find Full Text PDFProstate cancer (PCa) outcomes vary significantly across risk groups. In early-stage localized PCa, the functional outcomes following radical prostatectomy (RP) can be severe, prompting increased interest in focal therapy, particularly High-Intensity Focused Ultrasound (HIFU). This study is to summarize the current clinical trials of HIFU on PCa.
View Article and Find Full Text PDFAims/hypothesis: Insulin resistance and compensatory hyperinsulinaemia are core features leading to beta cell failure in youth-onset type 2 diabetes. Insulin clearance (IC) is also a key regulator of insulin concentrations, but few data exist on IC in youth-onset type 2 diabetes. In a secondary analysis of our Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) randomised clinical trial, we investigated potential sex-, race-, ethnicity- and treatment-related differences in IC in youth-onset type 2 diabetes and aimed to identify metabolic phenotypes associated with IC at baseline and in response to metformin, metformin plus a lifestyle intervention, and metformin plus rosiglitazone.
View Article and Find Full Text PDFInjuries in weightlifting and powerlifting: an updated systematic review.
BMJ Open Sport Exerc Med
December 2024
Objective: To systematically review the literature on the incidence, prevalence, anatomical injury localisation and risk factors in Olympic weightlifting and powerlifting.
Design: Updated systematic review, PROSPERO registration (CRD42022382364).
Data Sources: Four databases (PubMed, Embase, SPORTDiscus and Web of Science) were searched on 19 February 2024.
Article Synopsis
- Genetic variants of long noncoding RNAs, specifically SNPs in CDKN2B-AS1, are linked to cancer risk and progression, with a focus on prostate cancer (PCa) in this study.
- Five SNPs were analyzed in a case-control study of 695 PCa patients and 695 healthy individuals, revealing that the rs1333048 variant increases the risk of developing aggressive tumors.
- Higher expression levels of CDKN2B-AS1 were found in individuals with the C allele of rs1333048, which correlated with larger tumors and worse outcomes, suggesting that this variant could influence the progression of prostate cancer.