[A root canal treatment that has proved to be ineffective: considerations, possibilities and choices].

If a root canal treatment has proved to be ineffective, different treatment options are possible. It starts, however, with the discussion whether the tooth can or should be saved. Many considerations play a role in this choice: the clinical and radiographic findings, the professional's ideas, the patient, the scientific insights that alter the value of various factors during evaluation and the availability of a good alternative treatment.

Improvements in Resilience, Stress, and Somatic Symptoms Following Online Resilience Training: A Dose-Response Effect.

Objective: To determine if participation in an online resilience program impacts resilience, stress, and somatic symptoms.

Methods: Approximately 600 enrollees in the meQuilibrium resilience program received a series of brief, individually prescribed video, and text training modules in a user-friendly format. Regression models tested how time in the program affected change in resilience from baseline and how changes in resilience affected change in stress and reported symptoms.

Muscle 3243A-->G mutation load and capacity of the mitochondrial energy-generating system.

Objective: The mitochondrial energy-generating system (MEGS) encompasses the mitochondrial enzymatic reactions from oxidation of pyruvate to the export of adenosine triphosphate. It is investigated in intact muscle mitochondria by measuring the pyruvate oxidation and adenosine triphosphate production rates, which we refer to as the "MEGS capacity." Currently, little is known about MEGS pathology in patients with mutations in the mitochondrial DNA.

The mitochondrial 13513G > A mutation is most frequent in Leigh syndrome combined with reduced complex I activity, optic atrophy and/or Wolff-Parkinson-White.

The m.13513G > A transition in the mitochondrial gene encoding the ND5 subunit of respiratory chain complex I, can cause mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) and has been reported to be a frequent cause of Leigh syndrome (LS). We determined the frequency of the mutation in a cohort of 123 patients with reduced complex I activity in muscle (n = 113) or fibroblast (n = 10) tissue.

[A non-healing dark area: surgical treatment or non-surgical retreatment?].

There are a lot of studies discussing success rates of root canal treatment. They show a big variety in their outcomes. Success rates are reported between 54 and 96 percent with a majority reporting a figure towards the higher end of the range.