Publications by authors named "M L Segall"
Purpose: Patients presenting with ureteral stones and concurrent urinary tract infections require prompt kidney drainage as per standard care guidelines. However, even in patients who are promptly drained and treated with appropriate antibiotics, the mortality rate due to urosepsis has been reported to be nearly 9%. Therefore, Predictive tools for early sepsis detection have become essential.
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- This study examines pelvic organ-preserving radical cystectomy in women with muscle-invasive bladder cancer, aiming to understand its oncological outcomes compared to standard radical cystectomy.
- A systematic review analyzed six studies totaling 597 patients, finding no significant differences in overall survival, cancer-specific survival, or recurrence-free survival between the two surgical approaches.
- While most studies had a moderate risk of bias, the findings suggest that pelvic organ preservation does not adversely affect cancer outcomes, but further research is needed for clearer insights.
Introduction: Percutaneous nephrolithotomy (PCNL) is the gold-standard treatment for large renal stones. One potentially significant complication of PCNL is blood loss, which can result in transfusion requirement and poorer stone-free outcomes. Tranexamic acid (TXA) has emerged as a promising intervention, administered systemically (TXA-S) or as part of irrigation fluid (TXA-I) in endourology.
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- Convergence in evolution can be studied by examining the bat genus Myotis, which exhibits three foraging strategies that have evolved independently.
- Researchers sequenced 17 bat genomes and analyzed over 16,000 genes to identify positive selections and evolutionary patterns in relation to their foraging strategies across 30 species.
- Key genomic changes linked to ecological adaptations involve alterations in genes related to sensory perception, fecundity, metabolism, and digestion, indicating that convergent evolution can occur through different genes with similar functions rather than the same specific genes.