Publications by authors named "M L Sassano"
Evidence on the associations of body size and occupational physical activity (PA) during the life course with gastrointestinal cancers is inconclusive. We analyzed data from the Golestan Cohort Study, a population-based prospective cohort study from Iran, with 50,045 individuals aged 40-75 years enrolled during 2004-2008 and followed through April 2023. Body size during adolescence, early adulthood, and at cohort baseline was assessed using validated pictograms.
View Article and Find Full Text PDFArticle Synopsis
- Recent studies indicate that PFAS exposure could raise the risk of certain cancers, particularly kidney and testicular cancers, but evidence for lung, head and neck, and thyroid cancers is less clear.
- A review of literature showed pooled relative risks (RRs) for occupational and environmental PFAS exposure: 1.20 for lung cancer, 1.15 for head and neck cancer, and 1.54 for thyroid cancer, though findings suggest the need for more thorough studies.
- Overall, while some associations between PFAS and lung or thyroid cancer were noted, especially with PFOS, the limited number of studies indicates a need for further research to validate these connections and consider other potential carcinogens.
The endoplasmic reticulum (ER) controls intracellular Ca dynamics. Depletion of ER Ca stores results in short-term activation of store-operated Ca entry (SOCE) via STIM1/Orai1 at ER-plasma membrane (ER-PM) contact sites (MCSs) and the long-term activation of the unfolded protein response (UPR), securing ER proteostasis. Recent work by Carreras-Sureda and colleagues describes a bidirectional control between IRE1 and STIM1 within the ER lumen that regulates ER-PM contact assembly and SOCE to sustain T-cell activation and myoblast differentiation.
View Article and Find Full Text PDFThis study explores the complementary or synergistic effects of medicinal cannabis constituents, particularly terpenes, concerning their therapeutic potential, known as the entourage effect. A systematic review of the literature on cannabis "entourage effects" was conducted using the PRISMA model. Two research questions directed the review: (1) What are the physiological effects of terpenes and terpenoids found in cannabis? (2) What are the proven "entourage effects" of terpenes in cannabis? The initial approach involved an exploratory search in electronic databases using predefined keywords and Boolean phrases across PubMed/MEDLINE, Web of Science, and EBSCO databases using Medical Subject Headings (MeSH).
View Article and Find Full Text PDFArticle Synopsis
- - Membrane contact sites (MCSs) help organelles coordinate activities, but their small size and dynamic nature make them hard to study with traditional imaging methods.
- - Researchers developed chemogenetic reporters that enhance the imaging of MCSs in both lab and living systems, enabling the exploration of complex biological questions.
- - They introduced a new biosensor, PRINCESS, which can detect MCSs and measure calcium dynamics simultaneously, revealing a mechanism where calcium signaling affects the positioning of the endoplasmic reticulum and mitochondria.