Publications by authors named "M L Reguly"
Benign prostatic hyperplasia (BPH) is the most common tumor in men over 40 years of age. Acute urinary retention (AUR) is regarded as the most serious hazard of untreated BPH. α-Blockers, such as doxazosin mesylate, and 5-α reductase inhibitors, such as finasteride, are frequently used because they decrease both AUR and the need for BPH-related surgery.
View Article and Find Full Text PDFThis study evaluated the clastogenic and/or aneugenic potential of three nucleoside reverse transcriptase inhibitors (zidovudine - AZT, lamivudine - 3TC and stavudine - d4T) using the cytokinesis-block micronucleus (CBMN) assay in human lymphocyte cultures. All three inhibitors produced a positive response when tested in binucleated cells. The genotoxicity of AZT and 3TC was restricted to binucleated cells since there was no significant increase in the frequency of micronuclei in mononucleated cells.
View Article and Find Full Text PDFArticle Synopsis
- The extract from Fill Magic Flow was found to increase mutant clone spots, indicating potential genetic damage through homologous recombination.
- Other extracts didn't show significant genetic effects, aligning with their safe use in dentistry, but raise concerns about the health risks associated with some composite resins for patients and dental staff.
Article Synopsis
- - Recent studies have explored adding paclitaxel (PAC) to the standard cisplatin (CIS) treatment for squamous cell carcinoma of the head and neck, targeting DNA and microtubules in cells.
- - A study using the wing Somatic Mutation and Recombination Test in fruit flies (Drosophila melanogaster) assessed the genotoxic effects of these drugs alone and in combination at different concentrations.
- - Findings indicate that while CIS caused significant DNA damage, PAC alone was not genotoxic; however, the combination's effect varied by concentration, suggesting PAC might reduce CIS's genotoxicity through its aneugenic activity.
Induced DNA damage by dental resin monomers in somatic cells.
Basic Clin Pharmacol Toxicol
February 2010
Article Synopsis
- A study examined the genotoxic effects of four dental resin monomers (TEGDMA, HEMA, UDMA, and BisGMA) using the Somatic Mutation and Recombination Test (SMART) in fruit flies.
- Results indicated that UDMA and TEGDMA significantly contributed to genetic mutations and homologous recombination, with UDMA being 1.6 times more genotoxic than TEGDMA.
- In contrast, BisGMA and HEMA showed no significant genotoxic effects, highlighting the need to consider findings in relation to other bioassay data for clinical implications.