Diagnosis and Monitoring Pathways Using Non-Invasive Tests in Patients With Alpha-1 Antitrypsin Deficiency-Associated Liver Disease: Results From an Expert Delphi Panel.

Background And Aims: The severe alpha-1 antitrypsin deficiency (AATD) genotype Pi*ZZ increases the risk of liver disease (AATD-LD) and lung disease. While non-invasive tests (NITs) are widely used for fibrosis stage and monitoring of all liver diseases, the consensus for use in AATD-LD is limited. A Delphi panel study was conducted to address this need.

Pediatric trauma over a decade: demographics, mechanisms of injury, and mortality at a major Danish trauma center-a retrospective cohort study.

Background: In recent decades, the number of fatal accidents among children and adolescents has declined. Nevertheless, trauma remains a significant cause of death among children and adolescents in high-income countries, despite significant advancements in prevention and care. Pediatric trauma patients differ substantially from adults in terms of their physiology, anatomy, and daily activities; therefore, they show distinct injury patterns and require different care.

Practical Approach to CT-Guided Online Adaptive Radiotherapy for Abdominopelvic Tumors.

Adaptive radiation therapy (ART) represents an evolution in the field of radiation oncology, addressing the complexities of tumor motion and anatomical variability that often challenge conventional treatment techniques. In abdominopelvic cancers, where the proximity of organs at risk (OARs) and variability in patient anatomy necessitate precise dose delivery, online adaptive radiation therapy (OART) has emerged as a technique to limit dose to OARs while optimizing dose delivery to target volumes. Computed tomography-guided OART is a time-efficient modality utilizes high-resolution cone beam computed tomography (CBCT) and artificial intelligence (AI) to enable real-time plan adaptation to daily anatomical changes, improving target coverage and minimizing exposure to healthy tissues.

Transcatheter Repair in Posterior, Anterior, and Bileaflet Mitral Valve Disease: 1-Year Results From EXPANDed.

Background: Treating anterior and bileaflet mitral valve disease in patients with primary or degenerative mitral regurgitation (DMR) is considered more challenging than posterior leaflet repair.

Objectives: The aim of this analysis was to evaluate the impact of anterior, posterior, or bileaflet disease on outcomes following mitral transcatheter edge-to-edge repair (M-TEER) in the EXPANDed studies.

Methods: EXPANDed is a pooled, patient-level analysis of subjects undergoing M-TEER with the MitraClip G3 or G4 system as part of the contemporary EXPAND and EXPAND G4 studies.