Drug-induced impairment of mitochondrial fatty acid oxidation and steatosis: assessment of causal relationship with 45 pharmaceuticals.

Drug-induced liver injury (DILI) represents a major issue for pharmaceutical companies, being a potential cause of black-box warnings on marketed pharmaceuticals, or drug withdrawal from the market. Lipid accumulation in the liver also referred to as steatosis, may be secondary to impaired mitochondrial fatty acid oxidation (mtFAO). However, an overall causal relationship between drug-induced mtFAO inhibition and the occurrence of steatosis in patients has not yet been established with a high number of pharmaceuticals.

The Effect of Heat Shock on Seed Dormancy Release and Germination in Two Rare and Endangered L. Species (Fabaceae).

Many species exhibit seeds with physical dormancy (PY), but little is known about the ecological context of this dormancy. We focused on and , two threatened Sardinian endemic species inside the subgenus Bunge. Fresh seeds collected from the only two respective known populations were used to investigate the effect of mechanical scarification, heat shock, and water imbibition processes on PY release and germination.

Using Mediterranean Native Plants for the Phytoremediation of Mining Sites: An Overview of the Past and Present, and Perspectives for the Future.

Mining exploitation in the Mediterranean Basin has left evident scars on the environment, and poses serious risks for human health and biodiversity, especially when mine wastes are left abandoned. This review analysed the main issues of metal(loid)s pollution related to mine exploitation in the Mediterranean Basin. Here, a list of Mediterranean native plant species studied for phytoremediation is given and, considering their biological forms, vegetational types, and ecology, we categorised them into halotolerant and hydro/hygrophilous vegetation, annual and perennial meadows, garrigues and maquis, and high maquis and woods.

Greenhouse investigation on the phytoremediation potential of pioneer tree Mill. in abandoned mine site.

Tailings and mine dumps are often pollutant sources that pose serious environmental threats to surrounding areas. The use of pioneer vascular plants to extract or stabilize metals is considered among the more effective mine tailing reclamation techniques. The study aimed at evaluating the phytoremediation potential of in abandoned mine-tailing (SW-Sardinia, Italy).

Germination and early seedling development of Cambess. subsp. Bacch., Brullo & Giusso in the presence of arsenates and arsenites.

Arsenate, As(V), and arsenite, As(III), are the most available arsenicals present in the soil solutions, in particular in mine polluted substrates, and cause several symptoms of toxicity in plants (like inhibition of seed germination and reduction of seedling development). For these reasons, seeds germination studies are essential for the design of phytoremediation activities of mine sites. Seed germination and seedling development of subsp.