Stress Appraisal, Stress Mindset, and Perceived Pain During a Cold Pressor Test.

Background: Previous studies demonstrated that task-specific stress appraisals as well as the more general belief that stress is (mal)adaptive (i.e., stress mindset) can affect the stress response.

Public Health.

Background: Traumatic brain injury (TBI) is a risk factor for dementia and is linked to earlier age of onset. This study investigated whether later-life changes in everyday cognition and behavior - risk markers of AD - could be observed in cognitively unimpaired older persons who sustained suspected mild TBI (smTBI) earlier in life and whether these cognitive and behavioral changes behavior mediated the link between smTBI and daily function.

Method: Data for 1274 participants from the Canadian Platform for Research Online to Investigate Health, Quality of Life, Cognition, Behaviour, Function, and Caregiving in Aging (CAN-PROTECT) study were analyzed.

Task relevant autoencoding enhances machine learning for human neuroscience.

In human neuroscience, machine learning can help reveal lower-dimensional neural representations relevant to subjects' behavior. However, state-of-the-art models typically require large datasets to train, and so are prone to overfitting on human neuroimaging data that often possess few samples but many input dimensions. Here, we capitalized on the fact that the features we seek in human neuroscience are precisely those relevant to subjects' behavior rather than noise or other irrelevant factors.

[Mental illness in old age - why we need a new perspective].

The clinical pictures of older patients with mental illnesses are often very complex, individual disorders appear less distinct, which is also confirmed in epidemiological studies. The article develops the hypothesis of a dedifferentiation of clinical pictures in old age. Deficits in executive functions in old age are discussed as a possible cause.

Developing an adaptive paediatric intensive care unit platform trial with key stakeholders: a qualitative study.

Objectives: Platform trials were used successfully in adult populations during the COVID-19 pandemic. By testing multiple treatments within a single trial, platform trials can help identify the most effective treatments (and any interactions between treatments) for patients more quickly and with less burden for patients and their families. The aim of this qualitative research was to inform the design of the first adaptive platform trial for paediatric intensive care in the UK with young people, parents/carers and paediatric intensive care unit (PICU) staff.