Publications by authors named "M L Perl"
[Current surgical treatment concepts for traumatic thoracic and lumbar vertebral fractures in adults with good bone quality].
Unfallchirurgie (Heidelb)
December 2024
The surgical treatment of traumatic vertebral body fractures in patients with good bone quality is controversially discussed. The data situation is unclear and only of limited help due to mainly insufficient evidence. The surgical measures include an axially aligned reduction and an osteosynthesis which is stable under load so that immediate mobilization of the patient is possible.
View Article and Find Full Text PDFArticle Synopsis
- - The study compared image-guided navigation and robot-assisted solutions for minimally invasive spinal surgery (MISS) in terms of precision, time taken, and subjective feedback.
- - Both methods showed similar precision when instrumenting 90 pedicles, although the robot was initially slower, with a decrease in time noted during later trials.
- - Despite no significant time advantage for the robot system, the findings suggest a learning curve that could improve efficiency, indicating a need for further clinical research.
Article Synopsis
- Research shows a correlation between the gut microbiome and the effectiveness of cancer immunotherapy, specifically for CAR T cell patients.
- The study identifies pentanoate, a metabolite from commensal bacteria, as a key factor that enhances patient survival by improving CAR T cell performance in challenging tumor environments.
- Findings suggest that incorporating microbial metabolites like pentanoate into CAR T cell manufacturing can exploit metabolic pathways and epigenetic changes to enhance treatment outcomes.