Clinical Manifestations.

Background: Alzheimer's disease and related dementias (ADRD) are characterized by impairments in an individual's cognitive and functional abilities. Computerized cognitive tests have been shown to be effective in detecting mild cognitive impairment and ADRD but whether they can stage the ADRD disease remains to be studied.

Method: Retrospective analysis was performed on a BrainCheck dataset containing 1,749 ADRD patients with different cognitive and functional assessments completed for cognitive care planning, including the Dementia Severity Rating Scale (DSRS), the Katz Index of Independence in Activities of Daily Living (ADL), and the BrainCheck cognitive assessment battery (BC-Assess).

Clinical Manifestations.

Background: Previous validation studies demonstrated that BrainCheck Assess (BC-Assess), a computerized cognitive test battery, can reliably and sensitively distinguish individuals with different levels of cognitive impairment (i.e., normal cognition (NC), mild cognitive impairment (MCI), and dementia).

Ego networks associated with e-cigarette use among college fraternity students: a cross-sectional study.

Objective: To use egocentric network analysis (ENA) to identify how the role of social networks relates to e-cigarette use among college fraternity members.

Participants: 212 fraternity members participated in this study.

Methods: Hierarchical logistic regression analyses assessed the relationship between egocentric network variables and ever use and current use of e-cigarettes.

Residual force enhancement is not altered while force depression is amplified at the cellular level in old age.

Residual force enhancement (rFE) and residual force depression (rFD) are history-dependent properties of muscle which refer to increased and decreased isometric force following a lengthening or shortening contraction, respectively. The history-dependence of force is greater in older than younger human adults when assessed at the joint level. However, it is unclear whether this amplification of the history-dependence of force in old age is owing to cellular mechanisms or a consequence of age-related remodeling of muscle architecture.