Publications by authors named "M L Patitucci"
Article Synopsis
- - The liver is crucial for managing lipoproteins, and creating effective lipid-lowering therapies requires advanced in vitro models that mimic liver functions better than current hepatocyte-like cells (HLCs).
- - Researchers aimed to enhance HLC maturation by using a 3D model with Biomimesys®, which allows human-induced pluripotent stem cells (hiPSCs) to form functional liver organoids.
- - After a 28-day maturation, the liver organoids showed improved gene expression, better cell organization, and significant functional abilities, such as lipid accumulation and production of essential proteins, offering a valuable tool for studying lipoprotein metabolism.
Elevated circulating lipoprotein(a) (Lp(a)) is a genetically determined risk factor for coronary artery disease and aortic valve stenosis (Tsimikas, 2017). Importantly, the LPA gene, which encodes the apolipoprotein(a) (protein-component of Lp(a)), is missing in most species, and human liver cell-lines do not secrete Lp(a). There is a need for the development of human in vitro models suitable for investigating biological mechanisms involved in Lp(a) metabolism.
View Article and Find Full Text PDFDyslipidemia is a key modifiable causal risk factor involved in the development of atherosclerotic cardiovascular disease. Recently, the G protein-coupled receptor 146 (GPR146), a member of the G-coupled protein receptors' family, has been shown to be a regulator of plasma cholesterol. Inhibition of hepatic GPR146 in mice displays protective effect against both hypercholesterolemia and atherosclerosis.
View Article and Find Full Text PDFArticle Synopsis
- Light affects how plants respond to immune challenges, particularly against the fungus Botrytis cinerea, by modulating the activity of the photoreceptor phytochrome B (phyB).
- A low red/far-red light ratio (R:FR), signaling competitive growth conditions, reduces the expression of defense markers and alters sensitivity to jasmonate, which is a key plant hormone involved in defense mechanisms.
- The study indicates that this R:FR effect operates through a specific jasmonate receptor module, increasing the susceptibility of plants to fungal infections, especially in dense plant canopies, independent of salicylic acid signaling.
Aim: To analyse the correlation between production of angiogenic [vascular endothelial growth factor A (VEGF-A) and interleukin 8 (IL-8)] and lymphangiogenic factors (VEGF-C and D) and adaptation to high altitude (>8000 m). Erythropoietin (EPO) served as a positive control.
Methods: We analysed the percentage of oxygen saturation and the plasmatic contents of VEGF-A, C, D, IL-8 and EPO in seven mountaineers and four Sherpas during an expedition to Mount Everest.