Publications by authors named "M L Pallotta"
Article Synopsis
- Indoleamine 2,3-dioxygenase 1 (IDO1) is important for tumors to evade the immune system, acting both as an enzyme that breaks down tryptophan and as a signaling protein that supports immunosuppression in tumors.
- Researchers aimed to find a better way to inhibit IDO1 that would disrupt its enzymatic and signaling roles, leading them to discover a compound called VS-15.
- VS-15 effectively binds to the inactive form of IDO1, blocking its activity and its interaction with other proteins, which helps improve immune responses, particularly in pancreatic cancer patients, and points to new treatment possibilities in cancer immunotherapy.
Small synthetic oligodeoxynucleotides (ODNs) can mimic microbial nucleic acids by interacting with receptor systems and promoting immunostimulatory activities. Nevertheless, some ODNs can act differently on the plasmacytoid dendritic cell (pDC) subset, shaping their immunoregulatory properties and rendering them suitable immunotherapeutic tools in several clinical settings for treating overwhelming immune responses. We designed HIV-1-derived, DNA- and RNA-based oligonucleotides (gag, pol, and U5 regions) and assessed their activity in conferring a tolerogenic phenotype to pDCs in skin test experiments.
View Article and Find Full Text PDFThe dwarfing allele Rht14 of durum wheat associates with greater stigma length, an important trait for hybrid breeding, whilst major dwarfing alleles Rht-B1b and Rht-D1b showed little to no effect. Although much understudied in wheat, the stigma is a crucial component for attaining grain set, the fundamental basis for yield, particularly in hybrid production systems where successful grain set relies on wind-driven pollen dispersal by the male parent and effective pollen capture by the female parent. Females with long stigma that exsert early are thought to be advantageous.
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- - Cohesin is an essential protein complex that helps in holding chromatids together, regulating gene expression, organizing the genome, and maintaining stability, and mutations in this complex are common in various human cancers.
- - Researchers found that certain mutations in the cohesin complex interact with WNT signaling, particularly when cancer cells are treated with a GSK3 inhibitor called LY2090314, which resulted in the stabilization of a protein called β-catenin and altered gene expression.
- - This study highlights a potential cancer treatment strategy by targeting WNT signaling in tumors with cohesin mutations, suggesting that leveraging synthetic lethality could be an effective approach in cancer therapy.
Background: SMC1A is a subunit of the cohesin complex that participates in many DNA- and chromosome-related biological processes. Previous studies have established that SMC1A is involved in cancer development and in particular, is overexpressed in chromosomally unstable human colorectal cancer (CRC). This study aimed to investigate whether SMC1A could serve as a therapeutic target for CRC.
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