Air Quality Sensor Experts Convene: Current Quality Assurance Considerations for Credible Data.

Air sensors can provide valuable non-regulatory and supplemental data as they can be affordably deployed in large numbers and stationed in remote areas far away from regulatory air monitoring stations. Air sensors have inherent limitations that are critical to understand before collecting and interpreting the data. Many of these limitations are mechanistic in nature, which will require technological advances.

Treatment of COVID-19 Pneumonia and Acute Respiratory Distress With Ramatroban, a Thromboxane A and Prostaglandin D Receptor Antagonist: A Four-Patient Case Series Report.

Hypoxemia in COVID-19 pneumonia is associated with hospitalization, mechanical ventilation, and mortality. COVID-19 patients exhibit marked increases in fatty acid levels and inflammatory lipid mediators, predominantly arachidonic acid metabolites, notably thromboxane B >> prostaglandin E > prostaglandin D. Thromboxane A increases pulmonary capillary pressure and microvascular permeability, leading to pulmonary edema, and causes bronchoconstriction contributing to ventilation/perfusion mismatch.

Improving accuracy of air pollution exposure measurements: Statistical correction of a municipal low-cost airborne particulate matter sensor network.

Low-cost air quality sensors can help increase spatial and temporal resolution of air pollution exposure measurements. These sensors, however, most often produce data of lower accuracy than higher-end instruments. In this study, we investigated linear and random forest models to correct PM measurements from the Denver Department of Public Health and Environment (DDPHE)'s network of low-cost sensors against measurements from co-located U.

Assessment of mobile source air toxics in an Environmental Justice Denver community adjacent to a freeway.

Air pollutant concentrations are often higher near major roadways than in the surrounding environments owing to emissions from on-road mobile sources. In this study, we quantified the gradient in black carbon (BC) and air toxics concentrations from the I-70 freeway in the Elyria-Swansea environmental justice neighborhood in Denver, Colorado, during three measurement campaigns in 2017-2018. The average hourly upwind-downwind gradient of BC concentrations from the roadway was 500-800 ng/m, equal to an increment of approximately 30-80% above local background levels within 180 m of the freeway.

Motivation for Launching a Cancer Metastasis Inhibition (CMI) Program.

Metastatic cancers impose significant burdens on patients, affecting quality of life, morbidity, and mortality. Even during remission, microscopic metastases can lurk, but few therapies directly target tumor cell metastasis. Agents that interfere with this process would represent a new paradigm in cancer management, changing the 'waiting game' into a time of active prevention.