Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation.

Ergothioneine (ET), a dietary thione/thiol, is receiving growing attention for its possible benefits in healthy aging and metabolic resilience. Our study investigates ET's effects on healthspan in aged animals, revealing lifespan extension and enhanced mobility in Caenorhabditis elegans, accompanied by improved stress resistance and reduced age-associated biomarkers. In aged rats, ET administration enhances exercise endurance, muscle mass, and vascularization, concomitant with higher NAD levels in muscle.

Social Support Increases Resilience and Affect in Non-Displaced Ukrainians and Refugees After a Year of War.

Background: This study investigates the impact of social support on resilience and affect among Ukrainian individuals affected by war (non-displaced persons and refugees), one year after the onset of the conflict.

Method: A total of 344 participants were recruited and categorized into two groups: non-displaced individuals and refugees. Measures included the Scale of Positive and Negative Experience (SPANE), the Brief Resilient Coping Scale (BRCS), and the Multidimensional Scale of Perceived Social Support (MSPSS).

Disseminated Leiomyomatosis Following a Robotic-Assisted Myomectomy With Power Morcellation: A Case Report.

This case reports a 44-year-old female who presented to the gynecologic oncology clinic status post robotic-assisted laparoscopic myomectomy with intraperitoneal unprotected power morcellation in 2012, with an incidental finding of three conglomerate solid masses in the abdomen above the uterus, with each mass measuring approximately 15.5 cm. The patient underwent an exploratory laparotomy where multiple masses greater than 10 cm were found scattered throughout the abdominal cavity.

The complexities of aeronautical transfer of acutely unwell neurosurgical patients.

Objective: Neurosurgical care is difficult to access in many scenarios. Aeromedical evacuation of acutely unwell neurosurgical patients from remote, isolated or poorly equipped locations can be considered. This article aims to provide a framework of logistical factors which deserve special consideration in the preparation of these patients for transfer.