Publications by authors named "M L Monaghan"
Introduction: The shortage of physicians in rural Canada is a continuing challenge. Canadian medical schools have adapted strategies to increase the supply of rural physicians. This study appraises the effectiveness of the living library (also called Human Library©) in medical education, as an avenue for medical and pre-medical students to engage in dialogue with rural health professionals.
View Article and Find Full Text PDFWith no effective treatments for functional recovery after injury, spinal cord injury (SCI) remains one of the unresolved healthcare challenges. Human induced pluripotent stem cell (hiPSC) transplantation is a versatile patient-specific regenerative approach for functional recovery after SCI. Injectable electroconductive hydrogel (ECH) can further enhance the cell transplantation efficacy through a minimally invasive manner as well as recapitulate the native bioelectrical microenvironment of neural tissue.
View Article and Find Full Text PDFArticle Synopsis
- The PECOS study is investigating the long-term effects of pediatric SARS-CoV-2 infections by comparing infected and uninfected participants aged 0-21.
- Participants were assessed on various health metrics, including symptom reports, physical exams, and psychological surveys, revealing that those infected reported significantly worse outcomes in several health domains.
- The findings indicate that SARS-CoV-2 infection could negatively impact children's overall quality of life, highlighting the importance of ongoing research to understand these long-term effects.
Background: Hashimoto's thyroiditis' (HT) impact on the aggressive lymph node (ALN) status of papillary thyroid carcinoma (PTC) remains understudied.
Methods: Univariate and multivariate analyses assessed PTC aggressiveness markers, comparing PTC + HT to PTC alone from a single center retrospectively. ALN categorization included > 5 positive, ≥ 1 > 3 cm, and/or ≥ 4 with extranodal extension lymph nodes.
can induce trained immunity in murine macrophages offering protection against repeat exposure during skin infection. Here we demonstrate that exposure can result in non-specific trained immunity in humans and mice, enhancing macrophage responsiveness and bacterial clearance in a heterologous challenge. In humans, the enhanced macrophage responsiveness was accompanied by metabolic changes and histone modification.
View Article and Find Full Text PDF