Nanopore adaptive sampling accurately detects nucleotide variants and improves the characterization of large-scale rearrangement for the diagnosis of cancer predisposition.

Background: Molecular diagnosis has become highly significant for patient management in oncology.

Methods: Here, 30 well-characterized clinical germline samples were studied with adaptive sampling to enrich the full sequence of 152 cancer predisposition genes. Sequencing was performed on Oxford Nanopore (ONT) R10.

Effect of recording angle on accuracy of Kinovea-based kinematic gait analysis compared to three-dimensional motion analysis in healthy dogs: optimal at 90° recording angle.

Objective: The goal of this study was to investigate the effect of recording angle on the accuracy of 2-D Kinovea-based kinematic motion analysis (KMA) compared to 3-D KMA in dogs.

Methods: In this prospective study, 3-D marker-based KMA (VICON-Nexus, version 2.12.

Genomic analysis of adult thrombotic microangiopathies in less than 3 days: from rapid to fast genomics to treatment.

Using nanopore sequencing, we showed the feasibility and impact of rapid genomic screening for managing thrombotic microangiopathies in 18 prospective cases, achieving diagnoses in <3 days. We compared the results with standard exome sequencing, cost efficiency, and complement blockade initiation.

Accuracy of Kinovea-based kinematic gait analysis compared to a three-dimensional motion analysis system in healthy dogs.

Objective: The goal of this study was to compare the accuracy of kinematic measurements obtained using the 2-D video-based kinematic motion analysis (KMA) software Kinovea (version 0.9.5; http://www.

A framework for in-field and out-of-field patient specific secondary cancer risk estimates from treatment plans using the TOPAS Monte Carlo system.

. To allow the estimation of secondary cancer risks from radiation therapy treatment plans in a comprehensive and user-friendly Monte Carlo (MC) framework..