Publications by authors named "M L McHarg"
Secondary opportunistic coinfections are a significant contributor to morbidity and mortality in intensive care unit (ICU) patients, but can be difficult to identify. Presently, new blood RNA biomarkers were tested in ICU patients to diagnose viral, bacterial, and biofilm coinfections. COVID-19 ICU patients had whole blood drawn in RNA preservative and stored at -80°C.
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- Tumor necrosis factor inhibitors (TNFis) can cause the body to create antidrug antibodies (ADAs), which may lead to a decrease in treatment effectiveness for patients with noninfectious uveitis (NIU).
- The study aimed to investigate the frequency of ADAs and their relationship with drug levels and clinical outcomes in NIU patients receiving adalimumab or infliximab at the National Eye Institute from 2017 to 2021.
- Results showed that patients with detectable ADAs had significantly lower drug levels, indicating that ADA formation is linked to reduced effectiveness of TNFis in treating NIU.
Background: Coronavirus disease 2019 (COVID-19) systemic symptoms and sequelae have been studied extensively, but less is known about the characterization, duration, and long-term sequelae of ocular symptoms associated with COVID-19 infection. The purpose of this study was to analyze the frequency, spectrum, and duration of ocular symptoms in participants with COVID-19 infection treated in inpatient and outpatient settings.
Methods: A retrospective electronic survey was distributed to NIH employees and the public who reported testing positive for SARS-CoV-2.
Coronavirus disease 2019 (COVID-19) systemic symptoms and sequelae have been studied extensively, but less is known about the characterization, duration, and long-term sequelae of ocular symptoms associated with COVID-19 infection. The purpose of this study was to analyze the frequency, spectrum, and duration of ocular symptoms in participants with COVID-19 infection treated in inpatient and outpatient settings. A retrospective electronic survey was distributed to NIH employees and the public who reported testing positive for SARS-CoV-2.
View Article and Find Full Text PDFPractice patterns regarding regional corticosteroid treatment in noninfectious Uveitis: a survey study.
J Ophthalmic Inflamm Infect
January 2022
Background: Regional corticosteroid therapy for noninfectious uveitis is well-established but usage patterns have not been studied extensively. This study aims to assess practice patterns of retina and uveitis specialists regarding their preferences on the use of local corticosteroid therapy.
Methods: A 13-question survey was developed regarding the practice patterns of regional corticosteroid use in specific situations and populations.