Vaccine efficacy of NVX-CoV2373 against SARS-CoV-2 infection in adolescents in the USA: an ancillary study to a phase 3, observer-blinded, randomised, placebo-controlled trial.

Background: Although existing COVID-19 vaccines are known to be highly effective against severe disease and death, data are needed to assess their ability to reduce SARS-CoV-2 infection. We aimed to estimate the efficacy of the NVX-CoV2373 protein subunit vaccine against SARS-CoV-2 infection, regardless of symptoms, among adolescents.

Methods: We performed an ancillary observational study (SNIFF) to the phase 3, observer-blinded, randomised, placebo-controlled PREVENT-19 trial that assessed vaccine efficacy against symptomatic COVID-19 in the USA.

Moral conflict and moral distress in veterinarians: a mixed-methods approach.

Veterinary professionals are often confronted with moral conflicts from which moral distress can develop. Moral distress can lead to a cascade of deleterious processes and outcomes including emotional anguish, distress, reduced patient care, and attrition from both the workplace and workforce. The current study established a pilot measure for moral distress in Australian veterinary clinicians, as well as reporting additional sources of moral and ethical conflicts in veterinary practice.

Childcare as a social determinant of access to healthcare: a scoping review.

Introduction: As health systems strive to screen for and address social determinants of health (SDOH), the role of access to childcare and barriers to healthcare posed by childcare needs remains underexplored. A gap exists in synthesizing existing evidence on the role of access to childcare as a SDOH.

Methods: This scoping review aimed to examine and analyze existing literature on the role of childcare needs as a social determinant of access to healthcare.

Psychological, physical, and professional impact on second victims in veterinary anaesthesia: a cross-sectional international survey - Part 1.

Objective: To investigate the psychological, physical and professional impact of veterinary patient safety incidents (PSIs) on veterinary anaesthesia professionals.

Study Design: We conducted an observational cross-sectional survey, inviting veterinary anaesthesiologists, anaesthesiologists in training and veterinary nurses/technicians through social media platforms from 2 June 2023 to 20 September, 2023. The questionnaire was based on Second Victim Experience and Support Survey (SVEST) and analysed using descriptive statistics and subscale scoring to assess psychological, physical and professional impacts.

Energy metabolism in osteoprogenitors and osteoblasts: Role of the pentose phosphate pathway.

Bioenergetic preferences of osteolineage cells, including osteoprogenitors and osteoblasts (OBs), are a matter of intense debate. Early studies pointed to OB reliance on glucose and aerobic glycolysis while more recent works indicated the importance of glutamine as a mitochondrial fuel. Aiming to clarify this issue, we performed metabolic tracing of C-labeled glucose and glutamine in human osteolineage cells: bone marrow stromal (a.