Publications by authors named "M L Mascia"
The aims of this study were to investigate the prevalence of cryofibrinogenemia in a cohort of patients with systemic sclerosis (SSc) regardless of clinical manifestations, who were admitted to our hospital and determine the associations among CF positivity, disease features and ongoing therapies. This was a monocentric and retrospective study. The inclusion criteria were a diagnosis of SSc (according to the ACR/EULAR 2013 classification criteria), regular administration of i.
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- - This study focuses on developing new pyrazolo[1,5-a]quinazoline compounds that modify GABA receptors by incorporating oxygen or nitrogen at the 8-position.
- - The compounds were tested on defined GABA receptor types using an electrophysiological approach, identifying several promising candidates for further research based on their effects on chlorine currents.
- - Additionally, molecular modeling and statistical analysis (HCA) were used to classify the compounds according to their pharmacological effects, identifying key receptor residues that influence whether a compound acts as an agonist or antagonist.
Assessing evidence on the impacts of nature-based interventions for climate change mitigation: a systematic map of primary and secondary research from subtropical and tropical terrestrial regions.
Environ Evid
October 2023
Background: Nature-based interventions (NbIs) for climate change mitigation include a diverse set of interventions aimed at conserving, restoring, and/or managing natural and modified ecosystems to improve their ability to store and sequester carbon and avoid greenhouse gas (GHG) emissions. Recent projections estimate that terrestrial NbIs can lead to more than one-third of the climate change mitigation necessary to meet the Paris Climate Agreement by 2030. Further, these interventions can provide co-benefits in the form of social and ecological outcomes.
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- Coral reef fisheries are crucial for providing nutrients to coastal communities that are nutritionally at risk, and expanding marine protected areas (MPAs) can boost fish populations.
- Our study suggests that expanding sustainable-use MPAs could increase fish catch by up to 20%, potentially preventing millions of cases of micronutrient deficiency in reef nations.
- These findings are important as they align with global efforts to protect 30% of the ocean by 2030 and tackle malnutrition worldwide.
Clinical trials show that lumacaftor/ivacaftor (LUM/IVA) treatment has the potential to modify early cystic fibrosis (CF) disease progression in children as young as 2 years of age. To assess the long-term impact of LUM/IVA treatment on CF disease progression in children aged 2-5 years. This phase 2 trial had two parts: part 1, a 48-week, randomized, double-blind, placebo-controlled study of LUM/IVA in children aged 2-5 years (previously reported) was followed by a 48-week open-label treatment period in which all children received LUM/IVA (part 2; reported here).
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