Colorectal Cancer and Central Obesity.

Importance: The proportion of colorectal cancer (CRC) cases attributable to excess weight, known as population attributable fraction (PAF), has been commonly based on measures of body mass index (BMI). Central obesity metrics, such as waist circumference (WC) and waist to hip ratio (WHR), are potentially better indicators of adiposity and have demonstrated stronger associations with CRC incidence.

Objectives: To examine PAFs of CRC cases that are attributable to high WC and WHR and compare them to those attributable to high BMI.

LncRNAs Involved in Antioxidant Response Regulation as Biomarkers of Gestational Diabetes: A Study on , and .

Recent findings highlighted the potential of long non-coding RNAs (lncRNAs) as novel indicators of gestational diabetes mellitus (GDM), as they demonstrate altered expression in metabolic disorders, oxidative stress (OS) and inflammation (IFM). The aim of this study was to evaluate the diagnostic potential and prognostic significance of the OS/IFM-related lncRNAs H19, and in GDM and their correlations with redox status-related parameters. The relative quantification of selected lncRNAs from peripheral blood mononuclear cells (PBMCs) of GDM patients and controls (n = 50 each) was performed by qPCR.

Evidence of Left Ventricular Cardiac Remodeling After 6 Weeks of Sprint Interval Training.

Sprint interval training (SIT) leads to similar improvements in maximal oxygen uptake (V̇O) and maximal cardiac output as previously reported for traditional endurance training, but the exercise-induced effects on cardiac remodeling are still largely unknown. The aim of the current study was therefore to explore the effects of SIT on cardiac structure and function assessed by echocardiography in relation to, and controlling for, changes in both blood volume (BV) and heart rate (HR). Healthy men and women (n = 28) performed 6 weeks of SIT.

Overcoming underestimation of the share of colorectal cancer cases attributable to excess weight: a population-based study.

Objective: Previous research may have underestimated the relationship between overweight/obesity and colorectal cancer (CRC) risk by overlooking important potential sources of bias.

Methods: We used data from a large, population-based case-control study encompassing 7098 CRC cases and 5757 age- and sex-matched controls with comprehensive information on risk factors, including self-reported body weight. Multivariate logistic regression was used to assess the associations of BMI with CRC risk before and after considering prediagnostic weight loss, history of lower gastrointestinal endoscopy, and potentially increased CRC risk beneath the overweight threshold (BMI 25 kg/m).