Publications by authors named "M L Mandelli"
Based on historic observations that children with reading disabilities were disproportionately both male and non-right-handed, and that early life insults of the left hemisphere were more frequent in boys and non-right-handed children, it was proposed that early focal neuronal injury disrupts typical patterns of motor hand and language dominance and in the process produces developmental dyslexia. To date, these theories remain controversial. We revisited these earliest theories in a contemporary manner, investigating demographics associated with reading disability, and in a subgroup with and without reading disability, compared structural imaging as well as patterns of activity during tasks of verb generation and non-word repetition using magnetoencephalography source imaging.
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- Semantic dementia (SD) patients, particularly those with semantic variant primary progressive aphasia (svPPA) and semantic behavioral variant frontotemporal dementia (sbvFTD), exhibit challenges in identifying faces due to atrophy in the anterior temporal lobe (ATL).
- The study involved 74 SD patients and 36 healthy controls, who underwent various face recognition and semantic processing tests, alongside structural MRI scans to assess neural correlates.
- Findings indicated that while both patient groups struggled with semantic face tasks, they performed similarly on perceptual face tests, suggesting that perceptual deficits may not arise until later stages of the disease with more extensive ATL atrophy.
Developmental dyslexia is typically associated with difficulties in basic auditory processing and in manipulating speech sounds. However, the neuroanatomical correlates of auditory difficulties in developmental dyslexia (DD) and their contribution to individual clinical phenotypes are still unknown. Recent intracranial electrocorticography findings associated processing of sound amplitude rises and speech sounds with posterior and middle superior temporal gyrus (STG), respectively.
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- * Researchers used automated speech analysis on audio-recorded picture descriptions from 40 FTD patients and 22 healthy controls to identify linguistic features that could help distinguish between the two types of atrophy associated with each variant.
- * The analysis revealed key speech features that could differentiate between FTD patients and healthy controls as well as between the two variants of FTD, suggesting potential for a non-invasive diagnostic tool that correlates with specific brain areas involved in language and
Introduction: Frontotemporal lobar degeneration (FTLD) is associated with FTLD due to tau (FTLD-tau) or TDP (FTLD-TDP) inclusions found at autopsy. Arterial Spin Labeling (ASL) MRI is often acquired in the same session as a structural T1-weighted image (T1w), enabling detection of regional changes in cerebral blood flow (CBF). We hypothesize that ASL-T1w registration with more degrees of freedom using boundary-based registration (BBR) will better align ASL and T1w images and show increased sensitivity to regional hypoperfusion differences compared to manual registration in patient participants.
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