Geospatial Analysis of Hymenolepis (Rodentolepis) nana Infection Transmission in Schools among Children in Cusco, Peru.

Hymenolepis nana is an emergent parasitosis, and the role of schools in infection transmission is unclear. Data from a cross-sectional study evaluating children for H. nana infection in schools in three districts of Anta province in Peru were analyzed.

Effective microbial formulations using sustainable carriers for the remediation of plastic-affected soils.

The increasing use of mulching films in intensive agriculture, together with their inefficient end-of-life disposal, has led to a significant plastic accumulation in soils, which contributes to disrupting ecosystems. The aim of this work was to determine the ability of different sustainable carriers to harbor and introduce plastic-degrading microorganisms into contaminated soils to provide a biotechnological tool that potentially enhances plastic decontamination, ameliorating the harmful effect of this type of pollutant in soil. To this end, pure cultures and co-cultures of Bacillus subtilis and Pseudomonas alloputida (specialized plastic-degrading strains) were added to three sustainable carriers (vermicompost, biochar, and calcium alginate beads) for the preparation of microbial formulations.

Bilateral Adrenal Leiomyomas in a Pediatric Patient.

Adrenal leiomyomas are rare, benign tumors originating in the adrenal glands. They have a varied age of presentation, occur with a slight female predominance, and are typically unilateral, although bilateral cases can occur. Symptoms typically include abdominal or flank pain.

Sequencing by Expansion (SBX) - a novel, high-throughput single-molecule sequencing technology.

Remarkable advances in high-throughput sequencing have enabled major biological discoveries and clinical applications, but achieving wider distribution and use depends critically on further improvements in scale and cost reduction. Nanopore sequencing has long held the promise for such progress, but has had limited market penetration. This is because efficient and accurate nanopore sequencing of nucleic acids has been challenged by fundamental signal-to-noise limitations resulting from the poor spatial resolution and molecular distinction of nucleobases.

Health position paper and redox perspectives - Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases.

Nuclear factor erythroid 2-related factor 2 (NRF2) is a redox-activated transcription factor regulating cellular defense against oxidative stress, thereby playing a pivotal role in maintaining cellular homeostasis. Its dysregulation is implicated in the progression of a wide array of human diseases, making NRF2 a compelling target for therapeutic interventions. However, challenges persist in drug discovery and safe targeting of NRF2, as unresolved questions remain especially regarding its context-specific role in diseases and off-target effects.