Publications by authors named "M L Kriegel"
Objectives: This study aims to elucidate the microbial signatures associated with autoimmune diseases, particularly systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), compared with colorectal cancer (CRC), to identify unique biomarkers and shared microbial mechanisms that could inform specific treatment protocols.
Methods: We analysed metagenomic datasets from patient cohorts with six autoimmune conditions-SLE, IBD, multiple sclerosis, myasthenia gravis, Graves' disease and ankylosing spondylitis-contrasting these with CRC metagenomes to delineate disease-specific microbial profiles. The study focused on identifying predictive biomarkers from species profiles and functional genes, integrating protein-protein interaction analyses to explore effector-like proteins and their targets in key signalling pathways.
Article Synopsis
- The study investigates the challenges of accurately assessing airborne transmission risks in various venues during the COVID-19 pandemic, highlighting the need for better risk evaluation strategies.
- Results show that proximity to emission sources significantly increases infection risk, while far-field transmission is influenced by different ventilation methods and other factors like occupancy and mask usage.
- Displacement ventilation was identified as the most effective strategy for minimizing airborne transmission and reducing secondary infection cases, outperforming mixing and natural ventilation methods.
Objectives: This study aims to elucidate the microbial signatures associated with autoimmune diseases, particularly systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), compared with colorectal cancer (CRC), to identify unique biomarkers and shared microbial mechanisms that could inform specific treatment protocols.
Methods: We analysed metagenomic datasets from patient cohorts with six autoimmune conditions-SLE, IBD, multiple sclerosis, myasthenia gravis, Graves' disease and ankylosing spondylitis-contrasting these with CRC metagenomes to delineate disease-specific microbial profiles. The study focused on identifying predictive biomarkers from species profiles and functional genes, integrating protein-protein interaction analyses to explore effector-like proteins and their targets in key signalling pathways.
Sustained widespread deployment of clinically and cost-effective models of integrated pain care could be bolstered by optimally aligning shared stakeholder values.
View Article and Find Full Text PDFArticle Synopsis
- AICA ribosiduria is a rare disorder linked to developmental delays, seizures, and vision issues, caused by mutations in the ATIC gene.
- A teenage patient showed two specific mutations in ATIC, including one that had not been reported before.
- A purine-enriched diet reduced harmful substances in the body, suggesting that dietary changes could be a potential treatment for this condition.