Publications by authors named "M L Kelsten"
Therapeutic advances in breast cancer have significantly improved outcomes in recent decades. In the early setting, there has been a gradual shift from adjuvant-only to neoadjuvant strategies, with a growing focus on customizing post-neoadjuvant treatments through escalation and de-escalation based on pathologic response. At the same time, the transition from a pre-genomic to a post-genomic era, utilizing specific assays in the adjuvant setting and targeted sequencing in the advanced stage, has deepened our understanding of disease biology and aided in identifying molecular markers associated with treatment benefit.
View Article and Find Full Text PDFBackground: Most posterior spinal fusion (PSF) patients do not require admission to an intensive care unit (ICU), and those who do may represent an underinvestigated, high-risk subpopulation.
Objective: To identify the microbial profile of and risk factors for surgical site infection (SSI) in PSF patients admitted to the ICU postoperatively.
Methods: We examined 3965 consecutive PSF patients treated at our institution between 2000 and 2015 and collected demographic, clinical, and procedural data.
Article Synopsis
- - This research focuses on a special type of material called a three-dimensional anisotropic pentamode (PM), which can control sound speed in water based on direction of wave propagation.
- - The study aims to experimentally verify the sound speeds predicted by simulations, using 3D printed titanium samples tested in a water tank with a wave source.
- - A deconvolution method is used to analyze measurements from a hydrophone, and supporting simulations model how the PM material responds to sound waves.
Myxofibrosarcoma (MFS) is a well-recognized histotype of soft tissue sarcomas that generally presents with localized disease. Herein, we describe the case of a patient with metastatic MFS who experienced durable response to sixth-line therapy with temozolomide. Upon further progression, his tumor was notable for a high tumor mutational burden, and he was subsequently treated with seventh-line immunotherapy, atezolizumab, achieving a second durable response.
View Article and Find Full Text PDFStudy Design: Retrospective case series.
Objective: We sought to identify risk factors associated with surgical site infection (SSI) after posterior long segment spinal fusion (PLSF).
Summary Of Background Data: Patients who undergo PLSF may be at elevated risk of SSI.