The distribution and severity of lower-limb hypertonicity and spasticity differentially impacts walking speed in people with neurological injuries.

Purpose: To investigate the relationship between the distribution and severity of hypertonicity and spasticity on walking speed in people with neurological injuries.

Material/methods: This cross-sectional observation cohort study used the Modified Ashworth Scale (MAS) and Modified Tardieu Scale (MTS) to assess hypertonicity and spasticity of the gastrocnemius, soleus, hamstrings and quadriceps. Participants were classified as having a distal (gastrocnemius and/or soleus), proximal (hamstrings and/or quadriceps) or mixed distribution of hypertonicity or spasticity.

Untangling sporadic brain arteriovenous malformations: towards targeting the KRAS/MAPK pathway.

Brain arteriovenous malformations (AVMs) are vascular lesions characterized by abnormal connections between parenchymal arteries and veins, bypassing a capillary bed, and forming a nidus. Brain AVMs are consequential as they are prone to rupture and associated with significant morbidity. They can broadly be subdivided into hereditary vs.

SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts.

Previous studies highlight the potential for sodium-glucose cotransporter type 2 (SGLT2) inhibitors (SGLT2i) to exert cardioprotective effects in heart failure by increasing plasma ketones and shifting myocardial fuel utilization toward ketone oxidation. However, SGLT2i have multiple in vivo effects and the differential impact of SGLT2i treatment and ketone supplementation on cardiac metabolism remains unclear. Here, using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) methodology combined with infusions of [13C6]glucose or [13C4]βOHB, we demonstrate that acute SGLT2 inhibition with dapagliflozin shifts relative rates of myocardial mitochondrial metabolism toward ketone oxidation, decreasing pyruvate oxidation with little effect on fatty acid oxidation in awake rats.

The role of cholinergic signaling in multi-sensory gamma stimulation induced perivascular clearance of amyloid.

Modulatory neurotransmitters exert powerful control over neurons and the brain vasculature. Gamma Entrainment Using Sensory Stimuli (GENUS) promotes amyloid clearance via increased perivascular cerebral spinal fluid (CSF) flux in mouse models of Alzheimer's Disease. Here we use whole-brain activity mapping to identify the cholinergic basal forebrain as a key region responding to GENUS.