Deprescribing in Australian residential aged care facilities: A scoping review.

Objectives: Older adults residing in residential aged care facilities (RACFs) are particularly vulnerable to negative health outcomes from polypharmacy and suboptimal prescribing in the context of frailty and multimorbidity. Deprescribing, the intentional withdrawal of inappropriate medications, has been proposed as a promising approach to reduce polypharmacy-related harms. Examining current deprescribing interventions in RACFs would help identify gaps in research knowledge.

Identification of a RAB32-LRMDA-Commander membrane trafficking complex reveals the molecular mechanism of human oculocutaneous albinism type 7.

Commander is an endosome associated sixteen protein assembly that associates with the sorting nexin 17 (SNX17) cargo adaptor to regulate cell surface recycling of internalised integral membrane proteins including integrins and lipoprotein receptors. Mutations in Commander are causative for Ritscher-Schinzel syndrome (RSS), a multiorgan developmental disease associated with a core triad of cerebellar-cardiac-craniofacial malformation. Here, using unbiased proteomics and computational modelling, we identify leucine rich melanocyte differentiation associated (LRMDA) as a novel Commander binding protein.

Maternity care providers' experiences of work-related serious events (MATES): An International survey.

Internationally, many women experience physiological childbirth with positive experiences and good health outcomes for them and their baby. For some, due to health complications and context of childbirth they may experience or be perceived as having had a traumatic birth. Ultimately, whether an individual experiences an event as traumatic or not, is a personal experience.

Correction: Study Protocol for 'PsilOCD: A Pharmacological Challenge Study Evaluating the Effects of the 5-HT2A Agonist Psilocybin on the Neurocognitive and Clinical Correlates of Compulsivity'.

[This corrects the article DOI: 10.7759/cureus.78171.

Study Protocol for 'PsilOCD: A Pharmacological Challenge Study Evaluating the Effects of the 5-HT2A Agonist Psilocybin on the Neurocognitive and Clinical Correlates of Compulsivity'.

Background: Obsessive-compulsive disorder (OCD) is a complex condition marked by persistent distressing thoughts and repetitive behaviours. Despite its prevalence, the mechanisms behind OCD remain elusive, and current treatments are limited. This protocol outlines an investigative study for individuals with OCD, exploring the potential of psilocybin to improve key components of cognition implicated in the disorder.